健骨滴丸成型工艺研究  

Study on Moulding Technics of Jiangu Dropping Pills

作　　者：关书博[1,2] 郑洪新[1] 王景刚 李可强[1,4] 张振秋[1] 

机构地区：[1]辽宁中医药大学,辽宁大连116600 [2]沈阳市第二中医院,辽宁沈阳116600 [3]辽宁康辰药业有限公司,辽宁丹东118013 [4]辽宁省中药研究所,辽宁沈阳110161

出　　处：《辽宁中医药大学学报》2011年第4期56-57,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省人力资源与社会保障厅博士后基金资助项目(bsh2009051);中国博士后科学基金资助项目(20100471478)

摘　　要：目的:建立健骨滴丸的成型工艺。方法:以滴丸的溶散时限、圆整度及丸重差异作为综合评定指标,研究冷却剂及其温度、基质、基质与药物的配比、滴制温度等因素对滴丸成型性的影响。结果:以二甲基硅油+液体石蜡(3∶1)作冷却剂,PEG4000-PEG6000(2∶3)为基质,药物-基质1∶2配比,滴制温度为80℃,冷却液温度15℃时,健骨滴丸成型质量最好。结论:该成型工艺稳定、可行。Objective：To establish an preparation process for Jiangu dropping pills.Methods：Choose resolving time,the spherical level of pills and variation of the pill weight as evaluation parameters,study on the influence of some factors on the forming process,such as the refrigerant,temperature of the refrigerant,the matrix,ratio of the drag and matrix,temperature of dropping and so on.Results：The optimum dropping conditions were as follows：the refrigerant was dimethyl silicone and ozocerite（3：1）;the matrix was PEG4000-PEG6000（2：3）;the ratio of the drag and matrix was 1：2;the dropping temperature was 80℃;the temperature of refrigerant was 15℃.Conclusion：The techniques are stable and feasible.

关 键 词：健骨滴丸 正交试验 制备工艺 

分 类 号：R283[医药卫生—中药学]