复方黄连降糖片对GK大鼠糖脂代谢紊乱的影响  

Efects of "FufangHuanglian Jiangtang Tablet" on Glucose and Lipid Metabolism in GK Rats

作　　者：周金芳[1] 宋菊敏[1] 刘小美[1] 戴珍妮[1] 

机构地区：[1]上海中医药大学基础医学院,上海201203

出　　处：《辽宁中医药大学学报》2011年第4期110-112,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市教育委员会基金资助项目(08cz05)

摘　　要：目的:观察复方黄连降糖片对2型糖尿病(T2DM)糖脂代谢紊乱的影响。方法:将27只GK大鼠按血糖随机分为模型组,复方黄连降糖片组(中药组)与二甲双胍组(西药组),饲以高脂饮食;另设Wistar大鼠12只作为正常组。各组给予饮用水或药物灌胃8周,并在治疗后测定空腹血糖(FPG)、糖负荷2h血糖(2hPG)、随机血糖(RPG)、糖化血红蛋白(HbAlc)、血清胰岛素(Ins)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肝脏甘油三酯(Liver-TG)。结果:与正常组比较,模型组大鼠出现糖脂代谢紊乱,血糖、HbAlc、LDL-C、Liver-TG、TC显著升高,Ins显著降低。与模型组比较,治疗组血糖、HbAlc、TC、LDL-C、Liver-TG均显著降低,Ins有升高趋势。结论:复方黄连降糖片能显著降低GK大鼠的血糖、HbAlc、TC、LDL-C、Liver-TG水平,从而调整其糖脂代谢紊乱状况。Objective：To study the efects of＂FufangHuanglian Jiangtang Tablet＂on Glucose and Lipid Metabolism in GK Rats.Methods：The 27 GK rats were randomly divided into 3 groups as model,zhongyao,western medicine group and takinghigh fat diet while the normal control group was set up using 12 healthy male Wistar rats.Each group was supplied corresponding drink water or medicine which last eight weeks.Then we measured the FPG,2hPG,RPG,HbAlc,Ins,TC,TG,LDL-C,HDL-C and Liver-TG.Results：In model group,the blood glucose,HbAlc,TC,LDL-C and Liver-TG were increased significantly,Ins was decreased.After drug treatment,in test group,the blood glucose,HbAlc,TC,LDL-C,Liver-TG were significantly decreased on different levels.Conclusion：FufangHuanglian Jiangtang Tablet can significantly decrease the blood glucose,HbAlc,TC,LDL-C,Liver-TG of GK Rats to regulate the disorder of Glycolipid metabolism.

关 键 词：复方黄连降糖片 糖脂代谢异常 自发性2型糖尿病大鼠 

分 类 号：R283[医药卫生—中药学]