再生内皮细胞表型改变在血管损伤性疾病中的作用  

Role of Regenerated Endothelial Cell Phenotypic Shift in Vascular Disease

作　　者：欧和生[1] 唐朝枢[1] 

机构地区：[1]北京医科大学第一医院中心实验室,北京100083

出　　处：《心血管病学进展》1999年第5期273-276,共4页Advances in Cardiovascular Diseases

摘　　要：血管内皮细胞(endothelialcell;EC)再生是血管内膜损伤或剥脱后的主要修复方式。然而,Koo等[1]于1989年应用血管体外培养发现,球囊拉伤后再生EC存在功能紊乱,并促进了再狭窄病变的发生发展。近来研究表明,EC再生的过程不仅参与血管内膜的修复,而且也参与动脉粥样硬化和再?..Vascular endothelial regeneration play a key role in regulating vascullar injury and recovery.As a major event of endothelial recovery,endothelial regeneration may take part in the pathogenesis of atherosclerosis and restenosis after angioplasty.There is a phenotypic shift between normal and regenerated endothelial cell.Changes of para/autocrine funtion in regenerated endothelial cell,due to the variety of cell phenotypic response,play an important role in regulating vascular tone and smooth muscle cell proliferation,which was a critical event in the neointimal formation of restenosis and the plaque of aterosclerosis.

关 键 词：血管损伤性疾病 再生内皮细胞 表型 

分 类 号：R543[医药卫生—心血管疾病]