不同灸治时间对脾胃虚寒型浅表性胃炎胃肠激素的影响  

Influence of different moxibustion time on the gastrointestinal hormone of superficial gastritis patients due to the spleen and stomach weakness

作　　者：常小荣[1] 谢华[5] 严洁[1] 易展[1] 刘密[4] 易受乡[2] 岳增辉[3] 林亚平[3] 宋炯[5] 

机构地区：[1]湖南中医药大学针灸推拿学省级重点学科,长沙410007 [2]湖南中医药大学经穴脏腑相关重点研究室,长沙410007 [3]湖南中医药大学针灸生物信息分析重点实验室,长沙410007 [4]湖南中医药大学2008级博士研究生,长沙410007 [5]湖南中医药大学2008级硕士研究生,长沙410007

出　　处：《国际中医中药杂志》2011年第4期293-296,共4页International Journal of Traditional Chinese Medicine

基　　金：基金项目：国家重点基础研究发展计划973课题（项目编号：2009cB522904）;长沙市科技局重点项目（项目编号：K1005020-31）;湖南省教育厅重点课题（项目编号：08A048）

摘　　要：目的通过观察不同灸治时间治疗脾胃虚寒型浅表性胃炎患者的临床疗效和胃肠激素的变化，探讨艾灸温补效应的量效规律及对血清胃肠激素的调整作用。方法将84例脾胃虚寒型浅表性胃炎患者通过中心随机方法（由湖南中医药大学承担中心随机，通过手机短信申请获得随机分组信息）分为温和灸20min组、温和灸40min组、药物组各28例。观察3组治疗前后的前列腺素E2（PGE2）、生长抑素（SS）和表皮生长因子（EGF）含量的变化及不同时点的临床疗效。结果①治疗前后比较，3组疗效差异均无统计学意义（P〉均O．05）；②治疗后温和灸20min组、温和灸40min组、药物组的浅表性胃炎症状积分分别为（3．07±1．54）、（3．11±1．40）、（3．79±2．25），治疗结束后1个月随访，3组的症状积分分别为（2．25±1．32）、（2．57±1．10）、（4．11±2．48），与治疗前比较，差异均有统计学意义（P均〈0．01）；③治疗后，3组血清PGE2含量明显升高，分别为（33．751±1．267）pg／ml、（33．774±8．583）pg／ml、（32．583±8．259）pg／ml，与同组治疗前比较，差异均有统计学意义（P均〈0．05）；温和灸40min后，血清EGF含量明显升高（1．331±O．823）pg／ml，与治疗前比较差异有统计学意义（P〈0．05）。结论①三种治疗方法均有效，但组间比较，差异无统计学意义；在远期疗效上，灸法组优于药物组；②灸法对脾胃虚寒型浅表性胃炎的胃肠激素有一定调整作用。Objective Through observing the clinical effect and the changes of gastrointestinal hormones caused by the treatment of different moxibustion time of the superficial gastritis patients due to the spleen and stomach weakness, to investigate the regulation of the dose-effect relation and the adjustment fimction on gastrointestinal hormone of serum of patients caused by the warming and nourish effect with moxibustion. Methods Eighty-four superficial gastritis patients due to the spleen and stomach weakness were divided into group 1 （treated by warming moxibustion for twenty minutes） （n=28）, group 2 （treated by warming moxibustion for forty minutes） （n=28）, and drug （n=28） groups. The changes of the content of the Prostaglandin E2 （ PGE2 ）, Somatostatin （SS） and Epidermal growth factor （EGF） were observed before and after treatment between 3 groups and the clinical effect in different time. Results （1） All 3 groups were compared after treatment, their clinical effect had no significant difference （P〉0.05） ; （2） Compared with pre-treatment, the superficial gastritis symptom score had a very significant difference after the treatment （3.07± 1.54）, （3.11±1.40）, （3.79＋2.25） and during the 1 month follow-up （2.25± 1.32）, （2.57±1.10）, （4.11±2.48）, （P〈 0.01） ; （3） After treatment, the content of the PGE2 of the serum was increased obviously, compared with pre-treatment. There was a significant difference in each group （33.751 ± 1.267） pg/ml, （33.774± 8.583） pg/ml, （32.583 ± 8.259） pg/ml, （P〈0.05） ; After warming moxibustion for forty minutes, the content of the EGF of the serum was increased obviously, compared with pre-treatment, showing a significant difference （1.331 ±0.823）pg/ml, （P〈0.05） . Conclusion （1） All of the three treatment methods had significant curative effect, and the curative effect had no significant difference among these 3 groups. But the moxibustion groups were markedly higher than

关 键 词：温和灸 浅表性胃炎 脾胃虚寒证 胃肠激素 

分 类 号：R259[医药卫生—中西医结合]