雌激素硫酸转移酶在肥大乳房乳腺组织中的表达及意义  

Expression of estrogen sulfotransferase in the mammary gland of hypertrophic breast and its significance

作　　者：杨艳清[1] 孙家明[1] 李琼[1] 张瑞瑞[1] 郭科[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院整形外科,武汉430022

出　　处：《中华整形外科杂志》2011年第1期48-50,共3页Chinese Journal of Plastic Surgery

摘　　要：目的 探讨雌激素硫酸转移酶（estrogen sulftransferase,EST）在肥大乳房乳腺组织中的表达及其意义.方法 采用免疫组织化学EnVision二步法,检测EST在32例肥大乳房和15例正常体积乳房乳腺组织中的表达,以及不同类型肥大乳房（19例腺性肥大乳房和13例脂性肥大乳房）乳腺组织中EST的表达状况.结果 32例肥大乳房和15例正常体积乳房乳腺组织中EST阳性表达率分别为34.4%（11/32）和93.3%（14/15）,组间比较差异有统计学意义（P＜0.01）.EST在19例腺性和13例脂性肥大乳房乳腺组织中的阳性表达率分别为10.5%（2/19）和69.2%（9/13）,组间比较差异有统计学意义（P＜0.01）.结论 EST的表达减少或缺失,对肥大乳房的形成,尤其与腺性肥大乳房的关系较为密切.Objective To investigate the expression of estrogen sulfotransferase （EST） in the mammary gland of hypertrophic breast and its significance. Methods EST expression in the mammary gland was detected by EnVision two step method of immunohistochemistry in 15 cases with normal breasts and 32 cases with hypertrophic breasts, including 19 gland-associated cases and 13 fat-associated cases.Results The positive expression rate of EST in mammary gland was 34.4% （11/32 ） in hypertrophic group and 93.3% （14/15） in normal group, showing a significant difference between the two groups（P 〈0.01 ）. The positive expression rate of EST was 10.5% （2/19） in gland-associated group and 69. 2% （9/13） in fat-associated group, showing a significant difference between the two groups （P 〈 0.01 ）.Conclusions Decrease or deletion of EST in the mammary gland may be related to the development of hypertrophic breast, especially gland-associated hypertrophic breast.

关 键 词：雌激素硫酸转移酶 乳房肥大 

分 类 号：R655.8[医药卫生—外科学]