Epididymis cholesterol homeostasis and sperm fertilizing ability  

作　　者：Fabrice Saez Ouvrier and Joel R Drevet 

机构地区：[1]UMR GReD CNRS 6247, INSERM U931, Clermont Universite, Equipe ＇Epididyme et maturation des gametes＇, Aubiere cedex 63171, France

出　　处：《Asian Journal of Andrology》2011年第1期11-17,共7页亚洲男性学杂志（英文版）

摘　　要：Cholesterol, being the starting point of steroid hormone synthesis, is a long known modulator of both female and male reproductive physiology especially at the level of the gonads and the impact cholesterol has on gametogenesis. Less is known about the effects cholesterol homeostasis may have on postgonadic reproductive functions. Lately, several data have been reported showing how imbalanced cholesterol levels may particularly affect the post-testicular events of sperm maturation that lead to fully fertile male gametes. This review will focus on that aspect and essentially centers on how cholesterol is important for the physiology of the mammalian epididymis and spermatozoa.Cholesterol, being the starting point of steroid hormone synthesis, is a long known modulator of both female and male reproductive physiology especially at the level of the gonads and the impact cholesterol has on gametogenesis. Less is known about the effects cholesterol homeostasis may have on postgonadic reproductive functions. Lately, several data have been reported showing how imbalanced cholesterol levels may particularly affect the post-testicular events of sperm maturation that lead to fully fertile male gametes. This review will focus on that aspect and essentially centers on how cholesterol is important for the physiology of the mammalian epididymis and spermatozoa.

关 键 词：cholesterol homeostasis epididymosomes FERTILITY post-testicular maturation SPERMATOZOA 

分 类 号：Q959.478[生物学—动物学] S831[农业科学—畜牧学]