石膏样小孢子菌引起体癣二例及病原学研究  

Two cases of tinea caused by Microsporum gyeum and their pathogenic analysis

作　　者：刘伟[1] 陈伟[1] 王爱平[1] 万喆[1] 李若瑜[1] 

机构地区：[1]北京大学真菌和真菌病研究中心,北京大学第一医院皮肤性病科,100034

出　　处：《中华皮肤科杂志》2011年第2期137-138,共2页Chinese Journal of Dermatology

基　　金：国家自然科学基金（30970131）;北京市自然科学基金（7102149）

摘　　要：2例患儿以皮疹伴瘙痒就诊,均有宠物接触史,自行外用糖皮质激素类药物等均无效.真菌直接镜检可以见到皮屑中有链状孢子或菌丝,皮屑培养为石膏样小孢子菌,2菌株对酮康唑、咪康唑、联苯苄唑、特比萘芬、伏立康唑敏感.经口服特比萘芬和外用环吡酮胺进行治疗痊愈.Two patients were admitted to the hospital for 2-month history of pruritic eruptions on the forehead and 2-week history of pruritie eruptions on the leg, respectively. Both patients had a history of pet contact. Topical application of glucocorticoids did not work well. Dermatological examination revealed a patch measuring 5 cm ×6 cm on the forehead of one patient and a patch measuring 2 cm × 3 cm on the leg of the other patient. Both patches were surrounded by red papules and scaling. Microscopic examination of skin scales revealed hyphae and chain-like spores, and culture of skin scales grew Microsporum gyeum. Both the isolates of Microsporum gyeum were sensitive to ketoconazole, miconazole, bifonazole, terbinafine, and voriconazole. Both patients were healed after treatment with oral terbinafine and topical ciclopirox olamine.

关 键 词：石膏样小孢子菌 病原学 糖皮质激素类药物 体癣 特比萘芬 直接镜检 联苯苄唑 环吡酮胺 

分 类 号：R756[医药卫生—皮肤病学与性病学]