二仙汤对青春期肥胖雄性大鼠生长发育的早期干预作用  

Erxian Decoction intervening early in male rats with delayed puberty caused by diet-induced obesity

作　　者：张东方[1] 郑玉凤 赵书楷 袁长季[1] 

机构地区：[1]中国医科大学药学院,沈阳110001 [2]东北制药集团供销有限公司,沈阳110023

出　　处：《中药药理与临床》2010年第6期66-68,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：沈阳市科技局资助项目(F10-149-9-14)

摘　　要：目的:探讨二仙汤(EXD)对青春期肥胖大鼠发育迟缓的早期干预作用。方法:采用高脂饲料喂养大鼠6周建立肥胖大鼠模型,分别以1.0、2.0、4.0g/kg EXD早期干预7周,测量体重,体长,计算Lee's指数,称睾丸重量,计算脏器系数,睾丸组织显微观察,采用放射免疫法测定血清T、E2。结果:与空白对照组对比,EXD组大鼠体重、体长、Lee's指数、睾丸重量、T均明显改善;而各组大鼠E2均无显著性差异;正常对照组和EXD组大鼠睾丸生精小管发育正常,空白对照组部分大鼠睾丸生精小管出现异常。结论:高脂饲料能抑制大鼠生长发育,而二仙汤能有效改善营养型肥胖大鼠生长发育。Objective： We aim to evaluate potential activity of Erxian Decoction（EXD） in male rats with delayed puberty induced by obesity.Methods： Delayed puberty model of male Sprague-Dawley（SD） rats were established with high-fat diet and were treated by EXD extract for 7 weeks.Body weight,body length,Lee＇s index,testis weight,Serum testosterone（T） and estradiol（E2） were determined.Results： Body weight,body length,Lee＇s index,testes weight and testosterone of the EXD groups were significantly improved,compared with those of high-fat model group（p0.05）.E2 of all groups were non-significance of difference（P0.05）.Conclusion： EXD extract is effective to improve sexual developmental inhibition caused by diet-induced obesity.

关 键 词：二仙汤 青春期发育迟缓 肥胖 

分 类 号：R285.5[医药卫生—中药学]