Ellagic Acid-induced Hypercoagulable State in Animals:a Potentially Useful Animal Hypercoagulable Model for Evaluation of Anticoagulants  

作　　者：Na Liu Jun-tian Liu Qiang-zong Zhang 

机构地区：[1]Department of Pharmacology, Xi＇an Jiaotong University School of Medicine, Xi＇an 710061, China

出　　处：《Chinese Medical Sciences Journal》2010年第4期237-242,共6页中国医学科学杂志（英文版）

摘　　要：Objective To establish and evaluate a hypercoagulable animal model for the assessment of anticoagulants. Methods Forty mice, thirty-two rats, and twenty-four rabbits were randomly and equally divided into control group (saline) and three ellagic acid (EA)-treated groups (low, middle, and high doses). In the mice, bleeding time (BT) was estimated with tail transaction, and clotting time (CT) with template method. Prothrombin time (PT) and the activated partial thromboplastin time (APTT) in rats and rabbits were measured by means of Quick's one-stage assay and modified APTT assay respectively. In addition, thrombin activity was estimated in rats with PT assay using a hemagglutination analyzer. The circulating platelet aggregates were de- tected in rabbits through platelet counting and presented as the circulating platelet aggregate ratio (CPAR). Results EA shortened BT and CT in mice, PT and APTT in rats, and increased thrombin activity and CPAR, all in a dose-dependent manner. EA also brought reduction of PT and APTT in rabbits in dose- and time-dependent manners. Conclusion EA could induce hypercoagulable state through activating coagulation system and platelets in mice, rats, and rabbits.

关 键 词：ellagic acid hypercoagulable state COAGULATION platelet aggregation 

分 类 号：S823.2[农业科学—畜牧学] TS202.3[农业科学—畜牧兽医]