脑干中缝苍白核黑素皮素能系统参与能量代谢平衡的调节  

Melanocortin signals in the brainstem raphe pallidus play a major role in the coordinating regulation of energy balance

作　　者：雷留根[1] 陈宝生[2] 范伟 

机构地区：[1]郑州大学基础医学院人体解剖学教研室,郑州450001 [2]河南科技大学法医学院法医病理与临床教研室,洛阳471003 [3]Center for the Study of Weight Regulation ＆ Associated Disorders,Oregon Health ＆ Sciences University Portland, OR 97239-3098

出　　处：《解剖学杂志》2010年第6期749-753,共5页Chinese Journal of Anatomy

摘　　要：目的：研究脑干中缝苍白核黑素皮素能系统在能量代谢调节中的作用.方法：以免疫组织化学法检测黑素皮素能神经纤维在中缝苍白核内的分布;将黑素皮素4受体激动剂（α-MSH）/拮抗剂（AgRP）微量注入中缝苍白核观察其对耗氧量及进食的影响.结果：α-MSH能神经终末密集分布于中缝苍白核内,未见AgRP能神经终末.中缝苍白核注射黑素皮素4受体激动剂MTII可增加小鼠的耗氧量,并抑制大鼠进食;将黑素皮素4受体拮抗剂SHU9119注入中缝苍白核可使大鼠进食量增高.结论：中缝苍白核内表达黑素皮素4受体的神经元接受来自脑内黑素皮素能神经元的投射,参与机体对能量代谢和进食的调节.Objective： To study the role in the regulation of energy balance of the melanocortin signals in the raphe pallidus （RPa）. Methods： With immunohistoehemistry, cvmelanoeyte-stimulating hormone （a-MSH）-immunoreactive （IR） fibers and agouti-related proteirrIR （AgRP-IR） fibers in the RPa were investigated. Oxygen consumption and food intake was measured following RPa mieroinjeetion of the MCAR agonist MTII and antagonist SHU9119 in rodents Results： α-MSH-IR fibers were densely distributed in the RPa, and AgRP-IR terminals were not observed. Microin]ection of MTII into the RPa dose-dependently stimulated oxygen consumption and inhibited feeding; whereas mieroinjeetion of SHU9119 enhaneed feeding. Conclusion： These data suggest that RPa MCAR neurons play a major role in the coordinating regulation of energy balance

关 键 词：黑素皮素 进食 能量代谢 中缝苍白核 

分 类 号：R332.2[医药卫生—人体生理学]