不同强度脉冲电磁场对去势大鼠股骨生物力学特性的影响  

The effect of pulsed electromagnetic fields on the biomechanical properties of the femur in ovariectomized rats

作　　者：肖登[1] 何成奇[2] 何红晨[2] 

机构地区：[1]重庆医科大学附属第一医院康复医学科,重庆400016 [2]四川大学华西医院康复医学科

出　　处：《中华物理医学与康复杂志》2010年第12期898-901,共4页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的 研究不同强度低频脉冲电磁场对骨质疏松大鼠骨生物力学指标的影响,探讨脉冲电磁场治疗骨质疏松的最适强度.方法 按随机分组原则将50只雌性3月龄Sprague-Dawley大鼠分为5组：假手术对照组、模型对照组、0.77 mT组、3.82 mT组和9.87 mT组,每组10只.除假手术对照组以外,对各组动物去势造模.0.77 mT组、3.82 mT组和9.87 mT组大鼠每天在频率为8 Hz,磁感应强度分别为0.77 mT、3.82 mT和9.87 mT的磁场环境中干预40 min,共30 d.假手术对照组和模型对照组不干预.各组动物均于术后喂养30 d后股动脉放血处死,取右侧股骨测定生物力学特性（包括最大载荷、最大位移、最大能量吸收、最大应力、最大应变和弹性模量）.结果 3.82 mT组各项生物力学指标与模型对照组和0.77 mT组比较,差异有统计学意义（P＜0.05）;3.82 mT组最大位移、最大能量吸收、最大应力、弹性模量与9.87 mT组比较,差异有统计学意义（P＜0.05）.结论 磁感应强度为3.82 mT的PEMFs能明显改善骨质疏松模型大鼠股骨生物力学特性.Objective To observe the effect of pulsed electromagnetic fields （PEMFs） of different intensities on the biomechanical properties of the femur in ovariectomized rats so as to determine the intensity for the best therapeutic efficacy. Methods Fifty female Sprague-Dawley rats were randomly divided into （1） a sham-operated control group （no PEMF treatment） , （2） ovariectomized control group （no PEMF treatment） （3） ovariectomized group Ⅰ （PEMF treatment at 8 Hz and 0.77 mT intensity, 40 min daily for 30 days） （4） ovariectomized group Ⅱ （PEMF treatment at 8 Hz and 3.82 mT intensity, 40 min daily for 30 days） and （5） ovariectomized group Ⅲ（ PEMF treatment at 8 Hz and 9.87 mT intensity, 40 min daily for 30 days）. Except for the 10 rats of the sham-operated control group, all the others received a standard ovariectomy. Serum estradiol （E2） and the biomechanical properties of one femur （peak load, maximum displacement, maximum energy absorption, maximum stress, maximum strain and modulus of elasticity） were assessed after 30 days of PEMF treatment. Results In group Ⅱ the biomechanical properties of the femur were significantly better than in group Ⅰ or the ovariectomized control group. In groups Ⅰ and Ⅲ the biomechanical properties of the femur were not significantly better than in the sham-operated group. In group Ⅱ the biomechanical properties of the femur were significantly better than in groups Ⅰ or Ⅲ. Conclusion PEMFs at 3.82 mT can improve the biomechanical properties of the femur significantly.

关 键 词：脉冲电磁场 磁场强度 去势大鼠 生物力学特性 

分 类 号：R5[医药卫生—内科学]