血清基质金属蛋白酶9、糖基化终产物与糖尿病足的相关研究  

Serum matrix metalloproteinase-9 and advanced glycation end-products in diabetic patients with or without diabetic foot problems

作　　者：李志红[1] 房辉[2] 张云良[3] 郭淑琴[3] 张金库[4] 李海燕[5] 甄艳凤[1] 杨岳[2] 

机构地区：[1]河北医科大学内科学教研室,石家庄050017 [2]唐山市工人医院内分泌二科 [3]保定市第一中心医院内分泌科 [4]保定市第一中心医院病理科 [5]保定市第一中心医院皮肤科

出　　处：《中华内分泌代谢杂志》2010年第12期1061-1062,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：比较糖尿病足患者（糖尿病足组）、2型糖尿病但非糖尿病足患者（非糖尿病足组）及健康体检者血清基质金属蛋白酶9（MMP-9）、晚期糖基化终产物（AGE）水平.糖尿病患者MMP-9、AGE水平高于健康者,糖尿病足组MMP-9高于非糖尿病足组.血清MMP-9升高似可预测糖尿病足发生及足溃疡的预后.Abstract：Serum matrix metalloproteinase-9 （MMP-9）and advanced glycation end products （AGE）levels were measured in the diabetic patients with or without foot problems as well as in healthy retired people. In diabetic patients serum MMP-9 and AGE levels were significantly higher than those in healthy subjects. Median MMP-9 level in patients with diabetic foot was higher than that in diabetic patients without foot ulcers. Increased serum MMP-9 in diabetes might predict occurance of diabetic foot and poor wound healing of the foot ulcers.

关 键 词：糖尿病足 溃疡 基质金属蛋白酶9 糖基化终产物 晚期 

分 类 号：R686[医药卫生—骨科学]