不伴白蛋白尿的2型糖尿病患者肾小球滤过率危险因素分析  

Analysis of the factors related to glomerular filtration rate in type 2 diabetes without albuminuria

作　　者：卢筱华[1] 冯烈[1] 蒋亚斌[2] 周幼芬[3] 

机构地区：[1]暨南大学附属第一医院内分泌科,广东广州510630 [2]暨南大学附属第一医院急诊科,广东广州510630 [3]暨南大学附属第一医院省水电二局院区内科,广东增城511340

出　　处：《南方医科大学学报》2010年第11期2502-2504,共3页Journal of Southern Medical University

基　　金：广东省医学科研基金(A2006347)

摘　　要：目的探讨各种危险因素对不伴白蛋白尿的糖尿病患者肾小球滤过率(GFR)的影响。方法尿白蛋白排泄率(UAER)正常的2型糖尿病患者131例分为GFR正常组与GFR下降组,应用多元回归方法对GFR的有关危险因素进行分析。结果 GFR下降组的年龄、病程、高血压病史、收缩压、血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)均明显高于GFR正常组。多元回归分析显示SCr、年龄、收缩压、UA与GFR分别呈显著负相关。结论部分不伴白蛋白尿的2型糖尿病患者早期已出现GFR下降,SCr、年龄、收缩压、UA增高是早期GFR下降的主要标志,GFR与UAER联合测定能更全面反映糖尿病早期的肾脏损害。Objective To analyze the risk factors affecting the glomerular filtration rate（GFR） in type 2 diabetic patients without albuminuria.Methods A total of 131 type 2 diabetic patients with normal urinary albumin excretion rate（UAER） were divided into normal GFR group and decreased GFR group.The factors relevant to GFR were analyzed by multiple factors regression.Results Age,course of diabetes,systolic blood pressure,prevalence of hypertension,the level of serum creatinine（SCr）,blood urea nitrogen（BUN） and uric acid（UA） were significantly higher in decreased GFR group than in normal GFR group.Multivariate regression showed that SCr,age,systolic blood pressure,and UA were negatively correlated to GFR.Conclusion Reduced GFR occurs in some type 2 diabetic patients without albuminuria.SCr,age,systolic blood pressure and UA are the major factors related to decreased GFR.The degree of early renal damage in diabetic patients can be better evaluated by combining GFR and UAER.

关 键 词：2型糖尿病 肾小球滤过率 尿白蛋白排泄率 

分 类 号：R587.2[医药卫生—内分泌]