A型供体至O型受体肝移植临床研究  

Clinical study of blood type A donor liver transplantation in type O recipients

作　　者：林建华[1] 周杰[1] 林艺雄[1] 张起帆[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广东广州510515

出　　处：《南方医科大学学报》2010年第11期2519-2520,共2页Journal of Southern Medical University

摘　　要：目的分析A型供体至O型受体肝移植的临床效果及可行性。方法回顾我院2008年12月～2010年1月间6例A型供体至O型受体肝移植病例的临床资料,探讨A型供体至O型受体肝移植的治疗措施及临床效果,分析移植的可行性。结果 6例患者手术过程顺利,术后恢复良好,至今最长者已术后14月。除1例于术后5月余因肿瘤全身多处转移死亡外,其余5例均存活良好。其中1例于术后1周出现胆红素异常升高,考虑为急性排斥反应,予甲强龙冲击治疗后逐渐恢复正常,其余病例术后均未发生急性排斥反应,无胆管狭窄、胆漏等并发症。结论在紧急或特殊情况下进行A型供体至O型受体肝移植是可行的。Objective To study the clinical effect and feasibility of blood type A donor liver transplantation in blood type O recipients.Methods The clinical data were analyzed in 6 blood type O patients receiving transplantation of the liver grafts from blood type A donors.The clinical effect and outcomes of the transplantations were evaluated to assess the feasibility of ABO incompatible liver transplantation between type A donors and type O recipients.Results The operations and the postoperative recovery were smooth in all the 6 recipients.Only one patient died 5 months postoperatively due to liver tumor metastasis,and the other 5 patients survived with the longest survival reaching 14 months.Acute graft rejection occurred in one patient 1 week after the operation on account of abnormally elevated serum bilirubin level,which was successfully managed with immediate methylprednisolone therapy.No such complications as acute graft rejection,bile duct stenosis or bile leakage was found in the other patients.Conclusion Blood type A donor liver transplantation in type O recipient is feasible in emergency or other special conditions.

关 键 词：血型 A型供体 O型受体 肝移植 

分 类 号：R657.3[医药卫生—外科学]