乙胺碘呋酮和倍他乐克治疗室性早搏的疗效与安全性的Meta分析  

Efficacy and safety of amiodarone and metoprolol in the treatment of ventricular premature beats:a meta-analysis

作　　者：黄志军[1,2] 李桃[1,2] 杨淼泉 吴玉玲[1,2] 李雅玲[1,2] 

机构地区：[1]广东省人民医院 [2]广东省医学科学院药学部,广东广州510080 [3]广东药学院,2010届毕业生广东广州510006

出　　处：《南方医科大学学报》2010年第11期2577-2580,共4页Journal of Southern Medical University

摘　　要：目的评价国内用乙胺碘呋酮和倍他乐克治疗室性早搏的疗效和安全性。方法通过计算机全面检索1999～2009年中国知网、维普资讯网、Pubmed home。应用Cochrane协作网提供的Rev Man4.2软件系统评价,对符合纳入标准的30篇文献共计1188例患者进行Meta分析。结果 (1)使用乙胺碘呋酮与倍他乐克治疗室性早搏的合并检验分析,综合检验结果为:Z=1.25,P=0.21,OR=1.18,95%CI:0.91～1.54,倒漏斗图分析结果提示可能存在发表偏倚;(2)两组不良反应发生率比较综合检验结果:OR=1.96,95%CI:1.39～2.77,倒漏斗图分析结果提示可能存在发表偏倚。结论乙胺碘呋酮组治疗室性早搏的总有效率并不优于倍他乐克组,乙胺碘呋酮组不良反应率比倍他乐克组高。Objective To evaluate the efficacy and safety of amiodarone and metoprolol in the treatment of ventricular premature beats.Methods Controlled randomized clinical trials from 1999 through 2009 were retrieved in China HowNet,VIP Web,Pubmed home.Using Rev Man4.2 software provided by Cochrane Collaboration,Meta-analysis was conducted of 30 articles meeting the inclusion criteria involving a total of 1188 patients.Results Merged analysis of amiodarone and metoprolol in the treatment of premature ventricular merge showed a comprehensive test results of Z=1.25,P=0.21,OR=1.18,95%CI：0.91-1.54;funnel plot analysis suggested the possible presence of publication bias.The comprehensive test of the incidence of adverse reactions in relation to the two drugs resulted in an OR of 1.96（95%CI：1.39-2.77）,and funnel plot analysis also indicated publication bias.Conclusions The total response rate of amiodarone does not seem to be superior to metoprolol in the treatment of premature ventricular contractions,and amiodarone is associated with higher incidence of adverse reactions.

关 键 词：胺碘酮 乙胺碘呋酮 倍他乐克 美托洛尔 室性早搏 META分析 

分 类 号：R541.7[医药卫生—心血管疾病]