睡眠呼吸暂停低通气综合征对患者动脉僵硬度的影响  

Effect of obstructive sleep apnea hypopnea syndrome on arterial stiffness

作　　者：温朝阳[1] 童一砂[2] 李民[1] 李玉柱[3] 赵玉生[4] 韩斌[5] 李为民[5] 谢立新[3] 唐杰[1] 

机构地区：[1]解放军总医院超声科,北京100853 [2]澳大利亚墨尔本大学奥斯汀医院血管外科 [3]解放军总医院呼吸科,北京100853 [4]解放军总医院老年心血管病研究所,北京100853 [5]解放军总医院耳鼻喉科,北京100853

出　　处：《南方医科大学学报》2010年第12期2652-2654,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(30772298);科技部支撑计划课题(2009BAI87B05)

摘　　要：目的探讨睡眠呼吸暂停低通气综合征(OSAHS)对患者肱-踝脉搏波传导速度(b-aPWV)的影响。方法对24例诊断为OSAHS的男性患者(病例组)和22例男性健康个体(对照组)进行b-aPWV检测。两组患者均无高血压、冠心病、脑卒中,无颈动脉或上下肢动脉粥样硬化、动脉壁钙化或动脉瘤形成,两组间患者年龄、身高体重指数(BMI)无统计学差异,具有可比性。分析两组患者b-aPWV的差异。结果 OSAHS组b-aPWV值显著高于对照组(1346.86±123.48vs1237.91±84.46,P<0.01),b-aPWV阳性率显著高于对照组(13/24vs1/22,P<0.01)。结论与正常对照组相比,OSAHS患者b-aPWV值及其阳性率增高,动脉僵硬度增加。Objective To assess the effect of obstructive sleep apnea hypopnea syndrome （OSAHS） on brachial-ankle pulse wave velocity （b-aPWV） in untreated diagnosed patients. Methods This study involved 24 consecutive male patients with newly diagnosed untreated OSAHS （aged 39.13±8.31 years） and 22 normal male individuals （aged 39.59±10.86 years） matched for age and body mass index. Carotid and extremities ultrasound were performed in all the subjects,and none of them had atherosclerosis,arterial cacification,or aneurism. No subject had a history of hypertension,coronary heart disease or stroke. All the subjects underwent arterial stiffness evaluation by means of b-aPWV measurements. Results The b-aPWV in OSAHS patients was significantly higher than that in normal subjects （1346.86±123.48 vs 1237.91±84.46,P0.01）,and the rate of positive b-aPWV in OSAHS patients was significantly higher （13/24 vs 1/22,P0.01）. Conclusion The value and positive rate of b-aPWV in OSAHS patients are higher than those in normal people,suggesting increased arterial stiffness in OSAHS patients.

关 键 词：睡眠呼吸暂停低通气综合征 肱-踝脉搏波传导速度 超声 动脉僵硬度 

分 类 号：R56[医药卫生—呼吸系统]