季节性变应性鼻炎预防用药研究  

Prevention study of seasonal allergic rhinitis

作　　者：孟大为 暴继敏 孙静 李淑杰 马云鹏 李哲 李丹 

机构地区：[1]辽宁省金秋医院耳鼻咽喉科,辽宁沈阳110016 [2]辽宁省肿瘤研究所,辽宁沈阳110016

出　　处：《中国耳鼻咽喉头颈外科》2010年第12期622-624,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：科技部"十一五"科技支撑计划项目(2007BAI18B15);辽宁省科技厅攻关课题(20052250123-18)联合资助

摘　　要：目的探讨预防用药对季节性变应性鼻炎(AR)的疗效。方法经皮肤点刺试验确诊的季节性AR患者70例,在花粉期到来前2周,随机分为A组:20例,口服氯雷他定10 mg/d,共14 d;B组:20例,鼻喷布地奈德256μg/d,共14 d;C组:20例,口服氯雷他定10 mg/d联合鼻喷布地奈德256μg/d,共14 d;D组:10例,未提前用药。花粉期到来时A、B、C 3组停止用药,与D组同时给予口服安慰剂1次/d。分别于用药前(花粉飞散前2周)、用药2周时(花粉飞散时)、停药1周(花粉飞散后1周)、停药2周(花粉飞散后2周)、停药4周(花粉飞散后1个月)进行视觉模拟量表(visual analogue scale,VAS)及鼻结膜炎相关生活质量问卷(rhinoconjunctivitis quality of life questionnaire,RQLQ)评分,并行统计学分析。结果预防性用药2周后患者VAS评分C组<B组<A组<D组,其中A、B、C 3组与D组之间VAS评分均有显著性差异(F=127.486,P均<0.001);RQLQ评分C组<B组<A组<D组,F=4179.598,P<0.001,SNK法组间比较在α=0.05水准除A组、B组之间总体均数差异没有统计学意义外,其余任意两组间总体均数差异均有统计学意义;停药4周后A、B、C、D 4组间VAS评分相比较均无差异(F=0.148,P=0.928,P均>0.05);RQLQ评分比较均无差异(F=1.438,P=0.302,SNK法组间比较P均>0.05)。结论药物治疗可有效控制季节性AR的症状,极大改善其生活质量,但提前2周用药后停药,不能有效控制整个花粉期的过敏症状。OBJECTIVE To investigate the effect of medications on prevention of seasonal allergic rhinitis.METHODS Seventy patients with seasonal allergic Prevention study of seasonal allergic rhinitis MENG Dawei1,BAO Jimin1,SUN Jing2,LI Shujie1,MA Yunpeng1,LI Zhe1,LI Dan1（1 Department of Otolaryngology,Jinqiu Hospital of Liaoning Province,Shenyang,Liaoning,110016,China;2 Cancer Institute of Liaoning Province,Shenyang,Liaoning,110016,China）rhinitis who were diagnosed with skin prick tests were randomly divided into four groups.The patients took medications for 2 weeks before the beginning of the seasonal allergic rhinitis,group A with Loratadine 10 mg/d,group B with Budesonide 256μg/d,group C with Loratadine 10 mg/d and Budesonide 256μg/d,and group D without any medications.Each group had 20 patients except group D for 10 patients.On beginning of the allergic period,all the patients stopped using the medications and just took placebo once a day.The symptoms and the quality of life of the patients were recorded using VAS and RQLQ respectively at 2 weeks before？ying pollen,pollen period,and 1,2,4 weeks after pollen period.RESULTS The VAS and RQLQ scores of group C were the smallest,followed by group B,group A and group D when using prevention medications for 2 weeks.The scores in group A,B,C had significant difference compared with group D（P0.001）,but there were no difference between the group A and group B.After stopped using medications for 4 weeks,the VAS and RQLQ scores had no difference among the four groups（P0.05）.CONCLUSION Using medications for 2 weeks before the beginning of the allergic period can reduced the symptoms and improve the quality of life of the patients,but that can not control the allergic symptoms for the whole pollen season.

关 键 词：鼻炎 变应性 季节性 化学预防 疼痛测定 鼻结膜炎相关生活质量问卷 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]