透明质酸钠关节腔注射治疗膝骨关节炎疗效观察  

Effect of sodium hyaluronate intra-anticular injection on knee osteoarthritis

作　　者：王琪[1] 李众利[1] 刘玉杰[1] 王志刚[1] 蔡谞[1] 魏民[1] 傅仰木[1] 

机构地区：[1]解放军总医院骨科,北京100853

出　　处：《军医进修学院学报》2011年第4期321-322,380,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的观察透明质酸钠膝关节腔注射对不同程度膝骨关节炎的治疗效果,探究透明质酸钠对膝骨关节炎的适用范围。方法将118例膝骨关节炎患者(共145膝)按照HSS(Hospitl for Special Surgery)膝关节评分分为优、良、中、差四组,进行膝关节腔透明质酸钠注射治疗,分别于治疗前及治疗后3、6、12个月进行HSS膝关节评分。结果 HSS评分优、良组治疗后3、6、12个月比治疗前评分提高(P<0.05),HSS评分中、差组治疗前后评分差异无统计学意义(P>0.05)。结论轻、中度膝骨关节炎通过透明质酸钠膝关节腔注射治疗,具有积极的治疗效果,重度骨关节炎应用透明质酸膝治疗无明显疗效。Objective To investigate the applicability of sodium hyaluronate（SH） intra-anticular injection in treatment of knee osteoarthritis（KOA） by observing its therapeutic effect on KOA at different degrees.Methods One hundred and eighteen patients with KOA（145 knees） were divided into excellent,good,moderate and poor outcome groups according to the hospital for special surgery（HSS） score for their knees and treated with SH intra-articular injection.Their knees were scored with the HSS scoring system 3,6 and 12 months before and after treatment,respectively.Results The HSS score was significantly higher in excellent and good outcome groups 3,6 and 12 months after treatment than before treatment（P0.05）.No statistical difference in HSS score was observed between the moderate and poor outcome groups before and after treatment（P0.05）.Conclusion SH intra-articular injection has a rather good effect on mild and moderate KOA but has no statistical effect on severe KOA.

关 键 词：骨关节炎 膝 透明质酸 注射 

分 类 号：R684.3[医药卫生—骨科学]