脂蛋白脂酶基因多态性与飞行员血脂水平的关系  

Relationship between lipoprotein gene polymorphism and blood lipids in the pilots

作　　者：魏利召[1] 蔡庆[1] 刘红巾[1] 陈涛[1] 

机构地区：[1]空军总医院临床分子生物学研究中心,北京100142

出　　处：《军医进修学院学报》2011年第4期366-368,377,共4页Academic Journal of Pla Postgraduate Medical School

基　　金："十一五"全军医药卫生科研计划课题(08G045);空军"十一五"后勤科研计划空后医学领域项目(BKJ09J024)~~

摘　　要：目的了解脂蛋白脂酶(LPL)基因多态性与飞行员血脂水平的关系,为飞行员高脂血症的防治提供依据。方法采用聚合酶链反应-限制性片断长度多态性方法检测106例飞行员和98例健康对照者LPL基因HindⅢ、PvuⅡ和Ser447Ter位点多态性,并用常规方法测定其血脂水平。结果飞行员LPL基因HindⅢ、PvuⅡ和Ser447Ter位点多态性的基因型频率和等位基因频率与健康对照人群相比差异无统计学意义。飞行员的高脂血症患病率(52.83%)明显高于对照人群(29.59%)。LPL基因HindⅢ和Ser447Ter位点的不同基因型与飞行员血清TG和HDL-C水平相关,而PvuⅡ位点不同基因型与血清TG、TC和HDL-C水平相关。结论 LPL基因多态性影响飞行员不同个体间血脂水平,环境因素是引起飞行员高脂血症的重要作用因子。Objective To investigate the relationship between lipoprotein（LPL） gene polymorphism and serum lipids in the pilots.Methods The genotypes of LPL gene HindⅢ,PvuⅡand Ser447Ter sites were assayed by polymerase chain reaction-restricted fragments length polymorphism,and blood lipids were detected by stipulated methods on 106 pilots and 98 control subjects.Results There is no statistical difference in genotypes and alleles frequency of LPL gene HindⅢ,PvuⅡand Ser447Ter sites in the pilots and control subjects.Hyperlipidemia prevalence（52.83%） of the pilots is much higher than that of the control（29.59%）.There was a close relationship between different genotypes of LPL gene HindⅢ and Ser447Ter site and levels of triglyceride（TG） and high density lipoprotein cholesterol（HDL-C） in pilots,and there was a close relationship between different genotypes of PvuⅡsite and levels of TG,total cholesterol（TC） and HDL-C.Conclusion LPL gene polymorphism is a genetic factor on the pilot individual serum lipid levels,and environment factors are important in inducing hyperlipidemia of the pilots.

关 键 词：飞行员 脂蛋白脂酶 基因多态性 血脂 

分 类 号：R851.3[医药卫生—航空、航天与航海医学]