洗胃及血液净化技术对小儿急性毒鼠强中毒72例疗效分析  

Treatment of Tetremthylene Disulfotetramine Intoxication in Children by Gastric Lavage and Blood Purification Technology: 72 Cases Reported

作　　者：李国安[1] 李秋[1] 李少军[1] 范忠祥[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆400014

出　　处：《儿科药学杂志》2011年第2期16-19,共4页Journal of Pediatric Pharmacy

摘　　要：目的:对洗胃及血液净化技术治疗小儿毒鼠强(四亚甲基二砜四氨)中毒病例进行分析,以进一步指导临床治疗。方法:收集我院2001年7月1日至2010年7月31日近10年来治疗急性毒鼠强中毒患儿的临床资料,并进行回顾性分析。结果:72例中毒患儿中治愈70例,死亡2例。全部有神经系统症状,血清酶学检查提示心肌酶谱改变31例,肝功能异常22例,中枢神经系统损害是影响恢复的主要因素。4 h以内洗胃的患儿住院时间明显短于未洗胃和4 h以上洗胃的患儿,在洗胃基础上进行血液净化效果更好。结论:毒鼠强中毒患儿多数预后很好,毒鼠强对儿童损害的主要靶器官为脑、心肌、肝脏,4 h以内洗胃是较好的治疗措施,同时进行血液净化能明显提高疗效,缩短患儿住院时间。Objective： To investigate gastric lavage and blood purification technology for the treatment of children with Tetremthylene Disulfotetramine（Tetramine） poisoning for guiding further clinical treatment.Methods： The clinical and laboratory data of 72 children with acute Tetramine poisoning were retrospectively analyzed,who were admitted from 1 July,2001 to 31 July,2010.Results： Among 72 cases of poisoning in children,70 cases were cured,2 died,all had neurological symptoms;31 patients with myocardial enzyme changes,22 cases with abnormal liver function,the central nervous system damage was a major factor in recovery.Children who accepted gastric lavage within four hours had better results with the treatment and their general hospital stays were shortened compared to those who did not accept gastric lavage or accepted gastric lavage four hours after poisoning.There were significant differences（P0.05）.Conclusions： Most children with Tetramine have good prognosis,the main organs damaged by Tetramine are brain,heart and liver.Gastric lavage within 4 hours is a better treatment,at the same time can significantly improve the efficacy of blood purification,reducing the hospital stays of children.

关 键 词：洗胃 血液净化 毒鼠强 中毒 小儿 

分 类 号：R595.4[医药卫生—内科学]