脑蛋白水解物注射液联合促红细胞生成素治疗中重度HIE近期疗效观察  

The Observation for Short-term Curative Effect of Cerebroprotein Hydrolysate Combining Erythropoietin on Neonates with Moderate and Severe Hypoxic-ischemic Encephalopathy

作　　者：陈亮[1] 叶晓秀[1] 袁丹[1] 曾令梅[1] 潘静[1] 

机构地区：[1]四川省泸州市人民医院,四川泸州646000

出　　处：《儿科药学杂志》2011年第2期19-21,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察脑蛋白水解物注射液联合促红细胞生成素治疗新生儿缺氧缺血性脑病(HIE)的近期疗效。方法:将57例HIE患儿依据家长意愿分为治疗组和对照组,两组患儿均在对症支持治疗的基础上,治疗组34例使用脑蛋白水解物联合促红细胞生成素治疗,对照组23例仅使用脑蛋白水解物治疗,比较两组患儿神经系统症状体征的恢复时间及新生儿行为神经测定评分法(NBNA)评分结果。结果:治疗组生后第7天NBNA评分为35.50±2.57,有效率82.35%(28例);第14天NBNA评分为37.59±2.05,有效率91.18%(31例);第28天NBNA评分为38.97±1.75,有效率97.06%(33例)。对照组第7天NBNA评分为33.87±2.69,有效率56.52%(13例);第14天NBNA评分为35.26±3.43,有效率69.57%(16例);第28天NBNA评分为37.13±3.17,有效率78.26%(18例)。治疗组NBNA评分及有效率均明显高于对照组(P<0.05)。结论:早期使用脑蛋白水解物注射液联合促红细胞生成素治疗可以提高HIE的疗效,改善预后。Objective： To investigate the curative effect of cerebroprotein hydrolysate combined with erythropoietin on hypoxic-ischemic encephalopathy（HIE） in neonates.Methods： Fifty-seven cases of neonatal hypoxic-ischemic encephalopathy were divided randomly into treatment group（n=34） and control group（n=23）.In addition to individualized supportive treatment,patients in control group were treated with cerebroprotein hydrolysate,patients in treatment group were treated with cerebroprotein hydrolysate combined with erythropoietin.The duration of recovery and the changes of neonatal behavior neurological assessment（NBNA） in the two groups were compared.Results： Postnatal NBNA and effective rates at 7,14,28 day in treatment group were（35.50±2.57） 82.35%,（37.59±2.05） 91.18%,（38.97±1.75） 97.06% and in control group were（33.87±2.69） 56.52%,（35.26±3.43） 69.57%,（37.13±3.17） 78.26% respectively;the score of NBNA and effective rates of treatment group were obviously higher than control group with significant differences（P0.05）.Conclusions： Combination cerebrprotein hydyolysate with erythropoietin therapy can improve clinic curative effect in HIE neonates.

关 键 词：脑蛋白水解物 促红细胞生成素 新生儿行为神经测定评分法 新生儿 缺氧缺血性脑病 

分 类 号：R722.131[医药卫生—儿科]