不同甲型肝炎疫苗免疫效果和应急接种适宜技术研究(一) 桦甸市829名4～10岁儿童抗HAV、HBsAg和ALT检测结果分析  

Immune effect of different hepatitis A vaccine and emergency vaccination of appropriate technology study(1) Analysis on the results of anti-HAV,HBsAg,and ALT of 829 children at age of 4 to 10 in Huadian city

作　　者：王洪海[1] 范学彬[2] 姜桂秋 王艳萍[1] 刘娟[2] 陈超[3] 周剑惠[3] 曹风瑞[3] 潘飞[1] 

机构地区：[1]桦甸市疾病预防控制中心,吉林132400 [2]吉林市疾病预防控制中心 [3]吉林省疾病预防控制中心

出　　处：《医学动物防制》2011年第3期248-249,共2页Journal of Medical Pest Control

基　　金：国家科技支撑计划课题-传染病及病媒生物控制适宜技术研究项目<不同甲型肝炎疫苗免疫效果和应急接种适宜技术研究>(2008BAI56B02)

摘　　要：目的对桦甸市829名儿童的抗HAV、HBsAg和ALT检测结果进行分析,从而确定健康人群。方法采用整群随机抽样的方法,对1～3年级学生和学前班儿童进行体检和问卷调查,选择既往无甲肝病史和甲肝疫苗接种史的人群作为研究对象,检测其血液中抗HAV、HBsAg和ALT的情况。结果通过对829名学生进行检测,3项均为正常者为710名。结论通过检测,确定了健康人群,为评价疫苗的安全性、免疫原性,比较儿童接种不同类型甲肝疫苗后不同时间抗体水平变化,以及应急接种方案确定了研究对象。Objective To analysis the testing results of anti-HAV,HBsAg and ALT of 829 children in Huadian city,consequently,made sure the healthy population.Method Adopting randomly chester sampling method,students of grade 1 to grade 3 and preschool children had physical examination and questionnaires,selecting the people with no previous hepatitis A history and no hepatitis A vaccination history as research objects,testing anti-HAV,HBsAg and ALT in their blood.Results Examined 829 children,in them,710 were normal.Conclusions By detection,we made sure the healthy population,and provided research objects for evaluation vaccine safety,immunogenicity,compared antibody levels of children at different time of different hepatitis A vaccination types,and emergency vaccination program.

关 键 词：甲肝 疫苗 儿童 抗HAV HBSAG ALT 

分 类 号：R511.2[医药卫生—内科学]