已酮可可碱对支气管哮喘患者血凝状态和血液流变学的影响  

作　　者：王宇 彭石龙 

机构地区：[1]广东佛山市南海区盐步医院,528247

出　　处：《中国社区医师（医学专业）》2011年第10期41-42,共2页

摘　　要：目的:探索已酮可可(pentoxifyline,PTX)吸入治疗对支气管哮喘患者血凝状态和血液流变学的影响。方法:41例支气管哮喘患者,随机单盲分成两组:治疗组21例,PTX100mg加入生理盐水5ml经超声雾化吸入;对照组20例,糜蛋白酶5mg加入生理盐水5ml经超声雾化吸入。两组均2次/日,疗程2周。治疗前后常规检查肺功能(FEV1)、动脉血气、肝肾功能、血凝和血液流变学指标等。结果:治疗组治疗后PVC、D-二聚体、血浆黏度下降有显著差异(P<0.05),全血粘度(高切和低切)下降有极显著差异(P<0.01);PaCO2下降(P<0.01),PaO2及SaO2%增高(P<0.01);血肌酐降低(P<0.05)。而对照组各指标均无变化(P>0.05)。两组治疗前后肝功能及尿素氮无统计学差异(P>0.05)。结论:本试验表明:PTX吸入治疗对改善支气管哮喘患者高凝状态和血液流变学具有较好的疗效。Objective ：To study the The effects of inhaled Pentoxifyline （PTX） on the blood coagulable status and hemorheology in patients with bronchial asthma Methods ：41 cases were randomly divided into two groups by single blind. Treatment group：21 cases, PTX 100mg in 5ml normal saline. Control group：20 cases, chymotrpsin 5mg in 5ml normal saline. All cases were inhaled by ultrasonic nebulization, b. i. d. for 2 weeks. Before and after treat, puhnonary function （FEV1） ,arterial blood gas analysis,parameters of blood coagulability and hemorheolory were examined in all case. Results：After treatment, PCV, D - Dimer, blood viscosity and coagulable paramenters were significantly decreased（ P 〈 0. 05 or P 〈 0. 01 ）. With the improvement of the above parametem, PaCO2 decreased too （P 〈 0. 01 ） , PaO2 and SAO2% increased（P 〈 0. 01 ）. There are no significant changes in the control group.Conclusion ： Pentoxifyline （ PTX ） inhaletion has good effects on hypercogulable status and hemorheology in patients with bronchial asthma.

关 键 词：已酮可可碱 哮喘 血凝状态 血液流变学 

分 类 号：R135.2[医药卫生—劳动卫生]