和厚朴酚固体脂质纳米粒的制备及性质研究  

Preparation of honokiol solid lipid nanoparticles and their characteristic

作　　者：张卿[1,2] 张良珂[1,2] 袁佩[2] 汪程远[3] 

机构地区：[1]重庆医科大学药学院,重庆400016 [2]重庆医科大学生命科学院,重庆400016 [3]重庆工商大学药物化学与化学生物学研究中心,重庆400067

出　　处：《中草药》2011年第4期691-693,共3页Chinese Traditional and Herbal Drugs

基　　金：重庆市科委自然科学基金资助项目(CSTC;2008BB5397);重庆市渝中区科技计划项目资助(20100203);重庆市卫生局课题资助(2010-2-202)

摘　　要：目的制备具有缓释作用的和厚朴酚固体脂质纳米粒。方法采用乳化蒸发-低温固化法制备和厚朴酚固体脂质纳米粒,通过正交试验对处方进行优化,并对其包封率、粒径、体外释放等进行考察。结果制备的固体脂质纳米粒的平均粒径为159 nm,包封率为77.1%。结论乳化蒸发-低温固化法可用于制备和厚朴酚固体脂质纳米粒。Objective To prepare sustained-release honokiol solid lipid nanoparticles（H-SLN）.Methods The solid lipid nanoparticles were prepared by emulsion-evaporation-solidified at low temperature method.The optimum condition was performed based on the orthogonal design to examine the entrapment efficiency,the mean diameter of the particles and the release in vitro.Results The entrapment efficiency of honokiol in the nanoparticles was 77.1% and the mean diameter of the particles was 159 nm.Conclusion The emulsion–evaporation-solidified at low temperature method can be used to prepare honokiol solid lipid nanoparticles.

关 键 词：和厚朴酚 固体脂质纳米粒 乳化蒸发-低温固化法 缓释作用 正交试验 

分 类 号：R283.6[医药卫生—中药学]