迷迭香酸的药理学研究进展  

Advance in pharmacological research of rosmarinic acid

作　　者：周丹[1] 刘艾林[1] 杜冠华[1] 

机构地区：[1]北京协和医学院中国医学科学院药物研究所,北京100050

出　　处：《中国新药杂志》2011年第7期594-598,共5页Chinese Journal of New Drugs

基　　金："十一五"重大新药创制项目(2008ZX09401-004;2009ZX09301-003-2-1;2009ZX09302-003和2009ZX09501-021);卫生行业科研专项(200802041);北京市自然基金项目(7103172)

摘　　要：迷迭香酸是一种在自然界广泛分布的多酚羟基化合物,是紫苏、丹参等中草药的有效活性成分。体内、体外研究表明,迷迭香酸具有抗氧化、抗菌、抗病毒、免疫调节等药理作用,对肿瘤、器官移植排斥反应等疾病具有治疗或增效作用,对心血管系统和神经系统具有保护作用。药动学研究表明,迷迭香酸在体内可被代谢为结合态和/或甲基化的形式,主要经尿液排出体外。文中通过对近年来国内外文献的调研,从药理作用和药动学特性两方面综述了迷迭香酸的药理学研究进展。Rosmarinic acid is a polyphenolic natural product widely existed in many traditional Chinese herbs such as Perilla frutescens and Salviae miltiorrhiza.Rosmarinic acid exerts many pharmacological effects such as anti-oxidant,antibacterial,antivirus,immunosuppressing effects.It also has a protective effect on the cardiovascular system and a therapeutic effect on cancer and transplant rejection.Pharmacokinetic studies have shown that rosmarinic acid is absorbed,and metabolized as conjugated and/or methylated forms.It is mainly excreted from the body through urine.Based on the advanced research,the research progress of rosmarinic acid was analyzed and summarized.In this article,we briefly reviewed the pharmacological effects and metabolism of rosmarinic acid.

关 键 词：迷迭香酸 代谢 药理作用 

分 类 号：R961[医药卫生—药理学]