双歧杆菌预防化疗后肠道菌群失调症的临床研究  

Bifidobacterium to Prevent Intestinal Flora Imbalance after Chemotherapy Clinically

作　　者：李凯[1] 谭永刚[1] 李午生[1] 赵力[1] 邹华伟[1] 

机构地区：[1]中国医科大学附属盛京医院肿瘤科,辽宁沈阳110004

出　　处：《微生物学杂志》2011年第1期82-84,共3页Journal of Microbiology

基　　金：辽宁省教育厅课题资助(2007CB512702)

摘　　要：探讨双歧杆菌对乳腺癌患者由于化疗导致肠道菌群失调的预防作用。2010年在我科住院的98例乳腺癌患者,在第一周期化疗后有48例出现肠道菌群失调,发生率为48.9%;在3周后的第二周期化疗前1d予患者口服双歧杆菌(双歧杆菌乳杆菌三联活菌片,一次4片,一日2次),直至化疗后2周,肠道菌群失调例数减少到32例,发生率为32.7%。在前后两周期化疗期间监测血常规,粪便菌群失调检查。治疗周期出现菌群失调比例32.7%明显低于对照周期48.9%(P<0.05),双歧杆菌对乳腺癌患者化疗导致胃肠菌群失调有预防作用。The role of Bifidobacterium to prevent intestinal flora imbalance（IFI） caused by chemotherapy for breast cancer（Bc） was investigated.Among 98 cases of Bc in the department in 2010,after the first cycle of chemotherapy,the incidence rate of 48 cases had IFI was 48.9%.Three weeks after the day before the second cycle of chemotherapy the patients took oral bifidobacteria（Bifidobacterium-Lactobacillus triple viable piece,4 tablets every time and 2 times a day） until 2 weeks after chemotherapy.The number of cases of IFI reduced to 32 cases with incidence rate of 32.7%.During the two cycles of before and after chemotherapy routine blood and fecal flora imbalance tests were inspected.The proportion（32.7%） of patients appear flora imbalance in treatment cycles was significantly lower than the control period（48.9%）（P0.05）.Therefore,Bifidobacterium possessed the role to prevent IFI caused by chemotherapy of Bc patients.

关 键 词：双歧杆菌 化疗 肠道菌群失调 

分 类 号：Q939.93[生物学—微生物学]