8a间院内深部真菌感染的临床分布特点及耐药性分析  

Clinical Distribution Characteristics and Drug-Resistance Analysis of Deep Fungal Infection During 8 Years in the Hospital

作　　者：李正军[1] 陈淑兰[2] 路娟[2] 宋熙瑶[2] 刘文博[2] 罗文涛[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院检验科,黑龙江哈尔滨150086 [2]哈尔滨医科大学第一临床医学院微生物科,黑龙江哈尔滨150001

出　　处：《微生物学杂志》2011年第1期95-98,共4页Journal of Microbiology

摘　　要：了解深部真菌感染的临床分布特点及耐药情况,以指导临床合理应用抗真菌药物。回顾性分析近8a自住院患者送检标本分离的深部感染真菌,利用ATB FUNGUS3真菌药敏卡进行体外药敏试验。2003年至2010年共检出9 854株假丝酵母菌,检出率呈上升趋势,由2003年的19.9%上升至2010年的34.3%。院内深部感染的真菌主要分布于内科(55.9%);主要感染部位为呼吸道(84.6%);主要菌种为白色念珠菌(60.9%);非白色念珠菌比例逐年增高。真菌药敏试验结果表明,深部真菌对两性霉素B、伏立康唑和5-氟胞嘧啶耐药率分别为0.9%、4.0%和4.6%;对伊曲康唑的耐药率有上升趋势,为28%。临床深部真菌感染逐年增加,对唑类药物的耐药情况日趋严重。应重视临床真菌感染的病原学检查和耐药性监测,才能有效地控制深部真菌院内感染。Clinical distribution characteristics and drug-resistance status in deep fungal infection（DFI） in the hospital was approached in order to guide rational application of antifungal drugs.Retrospective reviews were performed to analyze the cases of DFI in recent 8 years.The results showed that 9854 Candida albicans strains were isolated during eight years of 2003 to 2010 with the rising trends of isolation rate.It rose from 19.9% in 2003 to 34.3% in 2010.The infection fungi mainly distributed in the internal medicine department（55.9%）;the main infected sites were respiratory tract（84.6%）,mainly C.albicans（60.9 %）,and non C.albicans were increasing year by year.The susceptibility test showed that the drug-resistance rate to amphotericin B,voriconazole and 5-fluorocytosine were 0.9%,4.0 % and 4.6 % respectively.The resistance rate to itraconazole showed upgrading tendency,it was 28.0%.The clinical DFI increased year by year,and the resistance situation to azoles worsened day by day.Therefore,close attention should be paid to the clinical fungal infections etiological detection and drug-resistance monitor,by doing so the intra-hospital DFI could be controlled effectively.

关 键 词：深部真菌感染 临床分布 耐药性 抗真菌药物 

分 类 号：R37[医药卫生—病原生物学]