疟原虫红前期适应性免疫相关机制的研究进展  

Advances in research on the mechanism of adaptive immunity to Plasmodium in the preerythrocytic stage

作　　者：彭小红(综述)[1] 黄复生(审校)[1] 

机构地区：[1]第三军医大学基础部病原生物学教研室,重庆400038

出　　处：《中国病原生物学杂志》2011年第3期223-225,219,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.30972570)

摘　　要：红前期是疟原虫进入宿主的第一个时期,阻断红前期疟原虫的发育,就能够从源头上阻断疟疾的发生和传播,有效的红前期疟疾疫苗对于控制疟疾的发病及阻断疟疾的传播有着重要意义。对红前期免疫机制的深入研究对于合理的红前期亚单位疫苗的设计具有重要的指导意义,本文仅就目前疟原虫红前期适应性免疫相关机制的研究做一综述。The preerythrocytic stage is the first stage of Plasmodium invasion.Interrupting parasite proliferation during the preerythrocytic stage can block the development and transmission of malaria.An effective vaccine specific to the preerythrocytic stage is highly significant in terms of controlling the development and prevalence of malaria.A thorough investigation of the mechanisms of protection from the preerythrocytic stage is crucial to designing a subunit vaccine specific to the preerythrocytic stage.Advances in research on the mechanisms of adaptive immunity to Plasmodium in the preerythrocytic stage are reviewed in this paper.

关 键 词：疟原虫红前期 树突状细胞 CD8+T细胞 综述 

分 类 号：R382.31[医药卫生—医学寄生虫学]