MIF和IL-6与胎膜早破关系的研究  

Significance of macrophage migration inhibitory factor and IL-6 in premature rupture of membranes

作　　者：王艳丽[1] 张洁[1] 申太峰[1] 

机构地区：[1]郑州市第一人民医院妇产科,郑州450004

出　　处：《医药论坛杂志》2011年第2期115-117,共3页Journal of Medical Forum

摘　　要：目的探讨胎膜早破时巨噬细胞移动抑制因子(MIF)在胎膜的表达和母血中白细胞介素-6(IL-6)的水平及其二者与绒毛膜羊膜炎之间的关系。方法采用免疫组化SP法检测60例足月胎膜早破(PROM)分娩组和40例足月非PROM分娩组胎膜中MIF的分布和表达,采用ELISA法检测两组孕妇血清IL-6含量,采用HE染色的方法确诊绒毛膜羊膜炎。结果 PROM组胎膜MIF表达和母血IL-6含量明显高于对照组。PROM组胎膜MIF表达和母血IL-6含量随着破膜时间延长升高。PROM绒毛膜羊膜炎组胎膜MIF表达和母血IL-6含量明显高于PROM非绒毛膜羊膜炎组。结论 MIF和IL-6在胎膜早破的发病机制中起着重要的作用,MIF及IL-6与绒毛膜羊膜炎关系密切。Objective To explore the expression of macrophage migration inhibitory factor（MIF） in fetal membranes and level of IL-6 in maternal sera of pregnant women with premature rupture of fetal membranes（PROM）,and their relationship with chorioamnionitis.Methods Using immunohistological method to investigate the distributions and expressions of MIF in the specimens of 60 full-term PROM patients and 40 full-term non-PROM patients.Using ELISA to test the level of IL-6 in pregnancy woman’s sera.Using HE staining to define histopathology diagnosis：chorioamnionitis and unchorioamnionitis.ResultsThe quantity of MIF positive cells in fetal membrane and the level of IL-6 in maternal sera in PROM patients were significantly higher than those in non-PROM patients.The quantity of MIF positive cells in fetal membrane and the level of IL-6 in maternal sera in PROM patients were increased with the prolongation of time of PROM.The quantity of MIF positive cells in fetal membrane and the level of IL-6 in maternal sera in PROM patients with chorioamnionitis were obviously higher than those in PROM patients without chorioamnionitis.Conclusions MIF and IL-6 play an important role in pathogenesis of PROM,MIF and IL-6 are related to chorioamnionitis closely.

关 键 词：巨噬细胞移动抑制因子 白细胞介素6 胎膜早破 绒毛膜羊膜炎 

分 类 号：R714.433[医药卫生—妇产科学]