脊髓胶质细胞活化与病理性疼痛调节  

Spinal cord glial activation and pathological pain modulation

作　　者：尹显和[1] 胡兴国[2] 曾因明[1] 

机构地区：[1]徐州医学院江苏省麻醉与镇痛应用技术重点实验室&江苏省麻醉学重点实验室,221002 [2]湖南省桃源县人民医院麻醉与重症医学科

出　　处：《国际麻醉学与复苏杂志》2011年第2期221-224,共4页International Journal of Anesthesiology and Resuscitation

基　　金：基金项目：湖南省科技计划一般项目资助课题（2009SK3018）

摘　　要：背景 研究表明脊髓胶质细胞（星形胶质细胞和小胶质细胞）在各种病理性疼痛模型中活化,并且活化的胶质细胞在各种病理性疼痛的发生和发展中具有重要作用.目的 探讨脊髓胶质细胞在病理性疼痛调节中的作用.内容 从脊髓胶质细胞活化参与病理性疼痛调节的生理基础,脊髓胶质细胞活化及其检测,脊髓胶质细胞活化与病理性疼痛和脊髓胶质细胞参与病理性疼痛的调节机制等几方面就与此有关的研究进展进行了综述.趋向 胶质细胞将继续引起疼痛研究者的关注,因为它为临床病理性疼痛的治疗提供了新的靶点.Background Considerable studies have demonstrated that activation of spinal cord glial cells （astrocytes and microglia） is a common phenomenon in various pathological pain models, and the activated glial cells play an important role in the development and maintenance of pathological pain. Purpose To explore the role of spinal cord glia in pathological pain modulation. Content This article reviews the research advances in the role of spinal cord glia. It focuses on the several aspects of spinal cord glia-the physiological basis of glia contributing to pathological pain, glial activation and its detection, activation of glia and pathological pain, and glial modulation of pain. Trend Glial cells have been drawing the attention of pain researchers because targeting spinal cord glia is a new view of clinical pain therapies.

关 键 词：脊髓 胶质细胞 病理性疼痛 

分 类 号：R402[医药卫生—临床医学]