拉米夫定治疗小儿慢性乙型肝炎临床疗效观察  

LAM treats Children Chronic Hepatitis B Clinical Effects Observation

作　　者：何炎坤 

机构地区：[1]广州市番禺何贤纪念医院感染科,广州511400

出　　处：《中国医药导刊》2011年第2期287-288,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察拉米夫定治疗小儿慢性乙型肝炎临床疗效。方法:将136例慢性乙型肝炎患儿随机分为观察组和对照组各68例。对照组予以干扰素α-1b300万U,肌注,隔日1次,共治疗6个月:观察组在对照组治疗基础上予以口服拉米夫定,按每日3mg/kg分别近似予以1/2片、2/3片3/4片或1片,1次/d,疗程为6个月。结果:观察组临床疗效总有效率为91.18%,与对照组总有效77.94%比较,差异有统计学意义(P<0.05);观察组HBVDNA阴转率91.18%、HBeAg阴转率79.41%、HBeAg血清转换率4 7.06%、YMDD变异率8.82%,均明显高于对照组(P<0.01)。结论:在应用干扰素基础上加用拉米夫定治疗小儿慢性乙型肝炎临床疗效肯定,二者存在互补效应,不仅能够增强抗病毒效果,同时还能降低复发率。Objective： Observe the clinical effects of LAM to treat children chronic Hepatitis B.Methods：Divided 136 sick children who attacked by chronic Hepatitis B randomly into observation group and control group each had 68 children.The control group was given by interferon α-lb300 10 thousand U ,intramuscular, once a time every other day,totally 6 months.The observation group was given LAM by per os on basis of treatment,each day 3mg/kg equivalent to 1/2 tablet,2/3 of tablet,or 3/4 of tablet or 1 tablet,one time/d,treatment was one month.Results：The total effective rate for observation group clinical effects was 91.18%,comparing with the contrast group＇s total effect of 77.94%,the discrepancy had statistic meaning （P〈0.05）.The observation group＇s HBVDNA conversion rate was 91.18%,HBeAg conversion rate was 79.41%,HBeAg serum conversion was 47.06,YMDD heteromorphosis rate was 8.82%,all of which were obviously higher than the contrast group（P〈0.0 l）.Conclusions： On basis of applying interferon,applying LAM to treat children chronic hepatitis B clinical effects were affirmative,the two methods were complementary, they could not only increase antiviral effects,but also could decrease recurrence rate.

关 键 词：慢性乙型肝炎 拉米夫定 小儿 疗效 

分 类 号：R725.1[医药卫生—儿科]