标准桃金娘油治疗慢性阻塞性肺疾病急性加重期的疗效观察  

Effects of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Treated with Standardized Myrtol

作　　者：温玉婷[1] 

机构地区：[1]广东省江门市中心医院呼吸科,广东江门529000

出　　处：《临床医学工程》2011年第4期540-542,共3页Clinical Medicine & Engineering

摘　　要：目的观察标准桃金娘油治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法将86例AECOPD患者随机分为对照组(A组,n=44)和治疗组(B组,n=42)。A组为抗生素及氧疗等基础治疗,B组为基础治疗外加口服标准桃金娘油治疗,300 mg×3次/天;14天后分别测定两组患者临床症状、生活质量及血气分析、肺功能等指标。结果 A、B组用药后临床症状评分为(4.6±0.8)分及(3.8±0.9)分;生活质量评分为:(7.2±0.9)分及(6.3±1.1)分。治疗组较对照组在治疗后临床症状、生活质量评分下降更显著;比较PaO2、PaCO2、氧合指数、肺通气功能等指标改善程度B组亦明显优于A组(P<0.05)。结论标准桃金娘油可改善AECOPD患者血气、肺功能及临床症状,提高生活质量,其作用机制可能与减轻气道炎症、修复气道粘液-纤毛清除功能有关。Objective To investigate the effects of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） treated with standardized myrtol.Methods 86 patients were randomly divided into control group（group A,n = 44） and treatment group（group B,n = 42）.All patients were treated with antibiotic and oxygen therapy.Standardized myrtol enteric coated soft capsules were given for group B but not for group A.After 14 days,the scores of clinical symptom,quality of life,blood gas analysis and pulmonary function were observed.Results The scores of clinical symptom after treatment were（4.6 ± 0.8） and（3.8 ± 0.9） in A and B groups respectively.And the quality of life scores were（7.2 ± 0.9） and（6.3 ± 1.1）.There were significant differences between the two groups.The blood gas analysis and pulmonary function were significantly improved in the treatment group（P 0.05）.Conclusion Standardized myrtol can improve blood gas,pulmonary function,clinical symptom and quality of life in AECOPD patients.The mechanism might be related on reducing air way inflammation and repairing airway mucus-ciliary clearance.

关 键 词：标准桃金娘油 慢性阻塞性肺疾病急性加重期 气道炎症 

分 类 号：R562.2[医药卫生—呼吸系统]