病毒唑治疗肾综合征出血热对肌酸磷酸激酸同工酶的影响  

The treatment effect of ribavirin to hemorrhagic fever with renal syndrom on the kinetics of serum creatine phosphate kinase isoenzyme

作　　者：张全荣[1] 唐荣福[1] 袁光辉[1] 罗朝霞[1] 

机构地区：[1]湖北医科大学附属第一医院,武汉430060

出　　处：《中华实验和临床病毒学杂志》1999年第3期266-268,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　探讨治疗肾综合征出血热（ＨＦＲＳ） 时，病毒唑（Ｒｉｂａｖｉｒｉｎ） 对肌酸磷酸激酶同工酶（ＣＫＭＢ） 的影响。方法　对１５５ 例肾ＨＦＲＳ患者在进行较大剂量Ｒｉｂａｖｉｒｉｎ 双盲随机对照治疗中对血清ＣＫＭＢ进行了动态观察，并将ＨＦＲＳ各期、各型病毒唑治疗组与对照组ＣＫＭＢ 水平进行了比较。结果　两组病例从发热期开始ＣＫＭＢ明显升高，恢复期时逐渐恢复正常，病毒唑组发热期ＣＫＭＢ 明显低于对照组，分别为５５－２５±１８－２５ＵＬ和６９－６３±２３－５２ＵＬ（ Ｐ＜ ０．０５） ；重、危型病毒唑组ＣＫＭＢ明显低于对照组，分别为４７－７４±２４－８２ＵＬ和６６－０８±２５－０１ＵＬ（ Ｐ＜０．０５） 。Objective To study the effect of ribavirin treatment on kinetics of serum creatine phosphate kinase isoenzyme(CK MB) of patients with hemoarrhagic fever with renal syndrome(HFRS).Methods CK MB levels in 155 HFRS patients treated with larger dose of ribavirin and with routine therapeutic dose were observed dynamicaly, using randomly controlled double blind method. In addition, CK MB levels in different disease phases and different clinical types of HFRS were compared.Results The results showed that CK MB levels were significantly increased in febrile phase and decreased gradually to normal during convalescent phase in both groups, but in febrile phase, CK MB levels in ribavirin treated group and control group were 55.25±18.25IU/L and 69.63±23.52IU/L, respectively, the treated group had a lower level ( P <0.05). The severe and critical group treated by ribavirin showed a lower CK MB level of 47.74±24.82IU/L, while the control group showed a higher level of 66.08±25.01IU/L( P <0.05).Conclusion These results indicated that an early application of large dose of ribavirin in treatment of HFRS can reduce the serum CK MB levels in patients with HFRS.

关 键 词：病毒唑 肾综合征出血热 CK-MB 治疗 

分 类 号：R512.805[医药卫生—内科学]