SLE并发鼻疽诺卡菌感染引起皮下及脑脓肿一例  

Subcutaneous and Brain Abscesses Caused by Nocardia farcinica Infection in a Patient with Systemic Lupus Erythematosus

作　　者：席丽艳[1] 鲁长明[1] 曾凡钦[1] 陈伟雄[1] 三上襄[2] 

机构地区：[1]中山医科大学孙逸仙纪念医院皮肤科,广州510120 [2]日本千叶大学医学真菌研究中心

出　　处：《中华皮肤科杂志》1999年第5期297-299,共3页Chinese Journal of Dermatology

摘　　要：目的　探讨一例SLE患者脑脓肿及皮下脓肿的病原菌。方法　从患者脑脊液和皮下脓肿取材 ,涂片Gram染色并培养。结果　涂片Gram染色阳性 ,培养菌落类似星形诺卡菌 ,但在生化特性方面略有不同 :抗酸性为阳性 ,尿素酶阳性 ,不分解酪氨酸、黄嘌呤 ,能发酵葡萄糖、鼠李糖、赤藓糖。可在 45℃生长 ,确证为鼻疽诺卡菌并证实此分离菌株对多种药物耐药。小鼠动物实验证明它可引起多发性脑脓肿。结论　鼻疽诺卡菌有致病性 ,多重耐药性 ,毒力强 ,尤其在SLE患者可致严重后果。Objective To study the pathogens of subcutaneous and brain abscesses in a patient with SLE Methods Specimens were taken from the leg abscess and spinal fluid of the patient Then, smear, Gram′s stain and culture were done to identify the pathogen Results A strain of Nocardia farcinica was isolated, which was Gram′s positive The colony was very similar to that of Nocardia asteroides in morphology and physiological characteristics, with a little difference in biochemical characteristics N Farcinica grew at 45℃; produced acid from glucose, rhamnose, or erythritol; did not decompose tyrosine and xanthine It was acid fast and hydrolyzed urea The strain was multi drug resistant and could cause multi abscesses in mice Conclusion N Farcinica is pathogenic, virulent and multi drug resistant, and could cause severe outcome, especially in SLE patients

关 键 词：系统性红斑狼疮 鼻疽诺卡菌 感染 脑脓肿 病理 

分 类 号：R593.241[医药卫生—内科学]