慢性阻塞性肺疾病急性发作期甲状腺激素水平的研究  

Serum level of thyroid hormone in patients with acute exacerbation chronic obstructive pulmonary disease

作　　者：张雪冬[1,2] 刘海波[1,2] 刘双[1,2] 

机构地区：[1]首都医科大学附属北京安贞医院 [2]北京市心肺血管疾病研究所感染科,北京100029

出　　处：《心肺血管病杂志》2011年第2期133-135,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨不同程度慢性阻塞性肺疾病急性发作期(AECOPD)甲状腺激素:三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺素(TSH)水平的变化及临床意义,比较AECOPD患者甲状腺激素水平与氧分压(PaO2)之间的关系。方法:选择AE-COPD患者组45例(轻中度患者组17例,重度患者组28例),对照组20例,检测血清甲状腺激素水平,AECOPD患者组未吸氧时抽取动脉血作血气分析。结果:2组AECOPD患者组FT3、T3水平与对照组比较差异均有统计学意义(P<0.01)。轻、中度与重度AECOPD患者组,2组间T3比较差异有统计学意义(P<0.05)。氧分压正常组及轻度缺氧组与中重度缺氧组T3、FT3比较差异有统计学意义(P<0.01);氧分压正常组与轻度缺氧组T3比较差异有统计学意义(P<0.05)。结论:AECOPD患者可以发生甲状腺激素水平改变,在不同程度上受到PaO2的影响。对血清甲状腺激素水平进行动态监测,有助于评估慢性阻塞性肺疾病(COPD)患者的病情。Objective：To investigate the changes of serum thyroid hormone（T3、T4、FT3、FT4 and TSH）and its clinical significance in patients with vary severity of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and the relationship between thyroid hormone and arterial partial pressure of oxy-gen（PaO2）.Methods：45 patients with AECOPD were divided into mild group（17 cases） and severe group（28 cases） according to the pulmonary function changes,twenty healthy persons were enrolled as control group.The serum thyroid hormone levels of all subjects were detected with chemiluminescence immunoassay.At the same time,arterial blood analysis of AECOPD patients without oxygen therapy were determined.Results：The difference of serum FT3 and T3between the group AECOPD patients and control group case had a statistical significance（P〈0.01）,the levels of T3 between mild and severe AECOPD group has obvious difference（P〈0.05）.The concentrations of serum FT3 and T3 between normal PaO2 group,mild hypoxia group and severe hypoxia group had a statistically significant difference（P〈0.01）.In addition,serum T3 of normal PaO2 group was high-er than of mild hypoxia group.Conclusion：The serum levels of thyroid hormone in AECOPD patients may change,which is influenced by PaO2 to same extent.The serum thyroid hormone monitoring dynamically is helpful to evaluate the status of COPD patients.

关 键 词：肺疾病 慢性阻塞性 甲状腺激素水平 急性发作期 血气分析 

分 类 号：R563[医药卫生—呼吸系统]