卡尔-费休滴定法测定有机锌盐药物中水分  

Determination of Moisture in Organic Zinc Drugs by Karl-Fischer Titration

作　　者：何新蕾[1,2] 郝二军[1] 程传玲[3] 徐桂清[1] 李伟[1] 胡志国[1] 

机构地区：[1]河南师范大学化学与环境科学学院,新乡453002 [2]漯河医学高等专科学校,漯河462002 [3]郑州轻工业学院食品与生物工程学院,郑州450002

出　　处：《理化检验（化学分册）》2011年第3期321-322,326,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：国家"863"计划资助项目(2004AAZZ3190);河南师范大学新引进博;硕士科研启动支持课题资助项目(No.522038)

摘　　要：采用卡尔-费休滴定法测定有机锌盐药物中水分时,改用甲醇-氨溶液(质量比180比1)作溶剂溶解试样。改进的溶剂利于有机锌盐药物的溶解及结晶水的释放。试验结果表明:有机锌盐药物中水分的测定值比药典法测定值高,相对标准偏差(n=5)在0.13%～0.36%之间。In the Karl-Fischer titrimetric determination of moisture in drugs of organic zinc salts, a modification was made by dissolving the sample with CH3OH-NH3 （180＋1 by mass） solution. It was found that the sample was easier to be dissolved and its water of crystallization was completely released by using this solvent. In analyzing 9 drug samples by the proposed method, results obtained were higher than those obtained by the pharmacopeial method. Values of RSD＇s （n=5） found were in the range of 0. 13%-0. 36%.

关 键 词：卡尔-费休滴定法 有机锌盐药物 水分 

分 类 号：O655.2[理学—分析化学]