艾司洛尔在老年患者全麻腹腔镜胆囊切除术的临床研究  

Study on clinical application of esmolol in general anesthesia in senile patients with laparoscopic cholecystectomy

作　　者：施燕飞[1] 王晓军[1] 刘如葵[1] 徐连生[1] 李雪刚[1] 汤荣兴[1] 张努[1] 

机构地区：[1]宜宾市第一人民医院,四川宜宾644000

出　　处：《临床和实验医学杂志》2011年第7期509-510,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨艾司洛尔对老年患者全麻腹腔镜胆囊切除术的有效性和安全性。方法选择60例美国麻醉师协会(ASA)I～II全麻腹腔镜胆囊切除术老年患者,麻醉诱导前静脉注射艾司洛尔0.5 mg/kg,然后以25μg/(kg.min)持续静脉输注,监测麻醉诱导前(T0)、插管前(T1)、插管后(T2)、插管后5 min(T3)、插管后10 min(T4)、拔管前(T5)、拔管后5 min(T6)的收缩压(SBP)、舒张压(DBP)、心率(HR)及术后苏醒情况、麻醉并发症。结果插管后、插管后5 min、插管后10 min、拔管前、拔管后5 min的收缩压、舒张压、心率与插管前比较差异均无统计学意义(P>0.05);术中无心律失常,术后24 h内随访无麻醉相关并发症。结论艾司洛尔可安全有效的用于老年患者全麻腹腔镜胆囊切除术,血流动力学稳定,术后苏醒快。Objective To study the efficacy and safety of esmolol applied in general anesthesia for senile patients with laparoscopic cholecystectomy.Methods The application of loading dosage of esmolol 0.5mg/kg before induction of anaesthesia and followed by infusion of 25 μg/（kg·min） was carried out during the operation,laparoscopic cholecystectomy under ASA I to II general anesthesia was carried out in 60 senile patients,their systolic blood pressure（SBP）,diastolic blood pressure（DBP） and heart rate（HR） were recorded before induction of anaesthesia,immediately after intubation,5 and 10 minutes after intubation,before and 5 minutes after extubation.At the same time,monitoring postoperative recovery situation and complications at 24 hours after anesthesia was also observed.Results There were no statistically significant difference（P0.05） observed immediately after intubation,5 and 10 minutes after intubation,before and 5 minutes after extubation among systolic blood pressure,diastolic blood pressure and heart rate as compared with those before intubation;and there were no arrhythmia and other postoperative complications happened within 24 h during follow-up.Conclusion Administration of esmolol in general anesthesia is safe and effective for senile patients undergoing laparoscopic cholecystectomy with good hemodynamic stability,and it may bring about quicker resuscitation.

关 键 词：老年患者 全麻 腹腔镜胆囊切除 艾司洛尔 血流动力学 

分 类 号：R614[医药卫生—麻醉学]