慢性阻塞性肺疾病与全身炎症反应相关性的研究进展  

Progress in research of chronic obstructive pulmonary disease associated with systemic inflammatory response

作　　者：王会娟[1] 王昌明[1] 

机构地区：[1]桂林医学院附属医院呼吸内科,541001

出　　处：《国际呼吸杂志》2011年第7期531-535,共5页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）反应不仅表现为肺部炎症，而且伴随全身性炎症反应。COPD导致的全身不良效应与全身炎症反应密切相关。COPD患者全身炎症程度以一些炎症介质和（或）标志物（如C反应蛋白，纤维蛋白原，不同的细胞因子，瘦素）的血浆水平升高为特点。这些生物标志物，氧化应激、外周血细胞等，可能参与机体一系列的病理生理过程。认识COPD全身性炎症反应，可能对COPD患者的诊断和治疗提供新的思路，对病情的评估和治疗有重要意义。Chronic obstructive pulmonary disease （COPD） respond not only to lung inflammation, but also with systemic inflammatory response. COPD adverse effects caused by the body is closely related with the systemic inflammatory response. COPD patients with systemic inflammation in some inflammatory mediators and （or） markers （such as C reactive protein, fibrinogen, different cytokines, leptin） is characterized by elevated plasma levels. These biomarkers, oxidative stress, such as peripheral blood cells, the body may be involved in the pathophysiology of a series. COPD awareness of systemic inflammatory response, may be the diagnosis and treatment of patients with COPD to provide new ideas, assessment and treatment of the disease is important.

关 键 词：慢性阻塞性肺疾病 全身炎症反应 生物标志物 

分 类 号：R563.9[医药卫生—呼吸系统]