辅酶Q_(10)对大鼠再灌注心肌损伤的效用  

The Effect of Coenzyme Q_(10) on the Reperfusion Myocardial Injury in Rats.

作　　者：张运生[1] 叶铭[1] 刘岐山[1] 吴再彬[1] 

机构地区：[1]南京铁道医学院医学科学研究所,南京210009

出　　处：《铁道医学》1990年第3期134-135,共2页Railway Medical Journal

基　　金：江苏省科委资助

摘　　要：SD大鼠40只,随机分为对照及辅酶Q_(10)(CoQ_(10))两组作结扎左冠状动脉5分钟后再灌注60分钟的实验。发现对照组心室纤颤死亡率为40％,CoQ_(10)组仅5％(P<0.02)。再灌注30分钟内对照组左室峰值压持续下降,而CoQ_(10)组则维持12kPa(90mmHg)以上,心功能得以保持;心肌电镜形态计量表明再灌注时对照组心肌及线粒体损伤明显,而CoQ_(10)组则接近于正常心肌,提示再灌注时CoQ_(10)可保护心肌。Forty SD rats were randomly devided into two groups, the control and Coenzyme Q_(10) treated groups. The reperfusion myoaardial injury of rat was observed for 60 minutes after temporary ligation of the coronary artery for 5 minutes. The results showed that ventricular fibrillation occurred in control and Coenzyme Q_(10) groups in 45% and 5% respectively (P<0.001) . Within 30 minutes of reperfusion, the left ventricular pressure decreased continuously in contlol group, while it maintained above 12kPa ( 90mmHg ) in the Coenzyme Q_(10) group, and thus, the cardiac funtion was reserved nearly normal. And during reperfusion, the ultrastructural injury of myocardium and mitochrondria was prominant in the control group, but essentially as normal myocardium in the Coenzyme Q_(10) group as assayed with morphometric score. It is suggested that Coenzyme Q_(10) possesses some protective effects on myocardium during reperfusion.

关 键 词：冠状动脉疾病 再灌注损伤 泛醌 

分 类 号：R541.405[医药卫生—心血管疾病]