脑外伤大鼠血液黏度、气体变化及其相关性研究  

Study on the blood viscosity and blood gas variations and their relativity after traumatic brain injury in rats

作　　者：赵秉江[1] 何晓东[1] 白德成[1] 

机构地区：[1]兰州大学基础医学院手术学研究所,甘肃兰州730000

出　　处：《中兽医医药杂志》2011年第2期17-19,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：甘肃省新药临床前研究重点实验室开放基金资助项目(GSKFKT-0703);甘肃省自然科学基金暨中青年科技基金项目(3ZS061-A25-089);兰州大学医学科研基金资助项目(010602)

摘　　要：目的:探讨脑外伤大鼠血液黏度和气体短期内的变化规律及其相关性,探寻其变化规律并分析变化原因。方法:通过大鼠脑外伤模型检测大鼠脑外伤后不同时间点右心房混合静脉血血液黏度和血液气体的变化。结果:脑外伤后血液黏度和对照组比较显著增高(P<0.05),在伤后30 min、1 d出现2次高峰;血液pH值在伤后30 min、1 d出现2次低峰,PCO2在伤后30 min、1 d出现2次高峰,PO2在伤后出现下降,12 h达到低峰。结论:脑外伤可致血液黏度增高、血液pH值下降、PCO2升高、PO2下降。Aim：To study the blood viscosity and blood gas variations and their relativity after traumatic brain injury in rats,and seek its discipline and reason for clinical treatments and hematology factor of secondary trauma.Methods： Brain injury model was used to detect blood viscosity and blood gas variations of mixed venous blood from right atrium in different time point in rats.Results：The blood viscosity of brain trauma group was significant higher than that of the control（P0.05）.Blood viscosity and PCO2 appeared peak value at 30 minutes and 24 hours post-injure;the pH value dropped to platykurtosis at 30 minutes and 24 hours post-injure;the PO2 went down gradually and went to platykurtosis at 12 hours.Conclusion：The brain trauma could increase blood viscosity and PCO2,and decrease pH value and PO2 in rats.

关 键 词：脑外伤 血液黏度 血液气体 

分 类 号：S859.7[农业科学—临床兽医学]