硬皮病患者手指高分辨率MR血管成像的研究初探  

High resolution MR angiography of digital arteries in systemic sclerosis patients on 3.0 T:preliminary study

作　　者：张薇[1] 许建荣[1] 路清[1] 叶霜[2] 刘晓晟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科,上海200001 [2]上海交通大学医学院附属仁济医院风湿免疫科,上海200001

出　　处：《磁共振成像》2011年第2期85-89,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的探讨高分辨率3D-TOFMR血管成像在硬皮病患者手指血管成像中的应用价值。方法实验组30例硬皮病患者(平均年龄35.4±8.9岁,平均发生雷诺现象时间3.2±2.7年),7例正常对照者(平均年龄30.7±3.5岁),在3.0T磁共振机器上进行高分辨率3D-TOF序列扫描并进行血管重建(TR/TE=19/4.4ms,FA=15°,层厚=1mm),扫描时间为8分22秒。两名高年资磁共振医师对成像效果、血管显影数量和血管横断面积进行测量和评价,对实验组和对照组的各组数据进行统计学分析,评价MRA对硬皮病患者血管成像的价值,并对硬皮病患者的血管受累程度进行分级。结果我们评价了除外大拇指以外的四根手指两侧的共8支指动脉,硬皮病(SSc)组的总的血管显示率为47.58%,第5支指动脉是最少受累的血管,总的显示率为70.97%。统计学分析显示:第1支血管(P=0.058)和第3支血管(P=0.093)的动脉直径在两组对照中无明显变化(P>0.05)。结论 MRA手指血管成像是一个行之有效的方法,可用来评价硬皮病患者手指动脉的受累程度。Objective： We sought to evaluate the use of high-resolution three-dimensional time-of-flight （3D-TOF） MRA at 3.0 T in the visualization of digital arteries in systemic sclerosis （SSe） patients. Materials and Methods： Thirty patients with SSc（mean±SD age 35.4 ± 8.9 years, median number of years since onset of Raynaud＇s phenomenon 3.2 ± 2.7 years） and 7 healthy controls （mean ± SD age 30.7 ±3.5 years） were examed on a 3.0 T MR system. A modified high-spatial-resolution（voxel size=0.35 × 0.35 × 0.5 mm^3） 3D- TOF MRA （TR/TE=19/4.4 ms, FA = 15°, slice thickness = 1 mm） were performed during a total scan time of 8 min 22 s. The source images and MIP reconstruction were studied, the digital arteries count and lumen area of the selective section of the vessel were measured independently by two experienced radiologists and compared with that of the control ones, and a four-level grading system was made according to the severity. Statistical analysis was performed with t test and P 〈 0.05 was used as the criterion. Reults： We detected the 8 digital arteries in the four fingers（without the thumb） of each case and got a 47.58% presentation in general in SSc group, and artery No.5 had the highest presentation rate （70.97%）. Statistics showed the digital artery No.1 （P= 0.058） and No.3 （P = 0.093） had no difference in the lumen area （P 〉 0.05）. Conclusion： MR angiography of the digital arteries in the described technique is a promising method for us to judge the severity of finger vessels involved in SSc patients.

关 键 词：磁共振成像 MR微血管成像 多层面重建 3D-TOF 指固有动脉 硬皮病 雷诺氏征 血管异常 

分 类 号：R445.2[医药卫生—影像医学与核医学] R593.25[医药卫生—诊断学]