丹参滴注液制备过程中酚酸类成分的变化研究  

Componential Changing of Phenolic Acids in the Preparation of Danshen Dripping Solution

作　　者：袁晓航[1] 葛婷婷[2] 程建明[2] 

机构地区：[1]江苏省无锡市中医院药剂科,江苏无锡214000 [2]南京中医药大学药学院,江苏南京210029

出　　处：《南京中医药大学学报》2011年第2期172-174,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：南京中医药大学校企合作项目(2009024)

摘　　要：目的研究丹参滴注液在制备工艺过程中原儿茶醛和丹酚酸B等水溶性成分的变化规律,为丹参滴注液质量标准的制定提供依据。方法采用RP-HPLC乙腈-0.5%冰醋酸系统梯度洗脱程序,考察在加热、醇、酸碱等条件下水溶性成分的变化规律。结果丹酚酸B减少,丹参素钠和原儿茶醛增加。结论在高温和酸碱条件下,丹酚酸B被降解为丹参素钠和原儿茶醛。OBJECTIVE To study changing regulation of protocatechuic aldehyde and salvianolic acid B in the preparation for Danshen Dripping Solution（DDS） and to provide reference for the drug＇s quality standard.METHODS Gradient separated method was applied.Mobile phase：acetonitrile-%5 acetic acid,DDS was detected by HPLC to inspect the changing regulation of the water-soluble components in the conditions of heating,alcohol,and acid base.RESULTS The peak area of salvianolic acid B decrease,while the peak area of Danshensu sodium and protocatechuic aldehyde increased.CONCLUSION In the condition of high temperature and acid base,salvianolic acid B hydrolyzes into Danshensu sodium and protocatechuic aldehyde.

关 键 词：丹参滴注液 原儿茶醛 丹酚酸B 酚酸类成分 

分 类 号：R284.1[医药卫生—中药学]