Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels  

作　　者：GUO Jin-shan LI Jian-zheng JING Xia-bin CHEN Xue-si HUANG Yu-bin 

机构地区：[1]State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China [2]Graduate School of Chinese Academy of Sciences, Beij＇ing 100049, P. R. China [3]Department of Materials Science and Engineering, Jilin University, Changchun 130022, P. R. China

出　　处：《Chemical Research in Chinese Universities》2011年第2期329-333,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China(No.2009CB930102);the National High-Tech Research and Development Program of China(No.2007AA03Z535);the National Natural Science Foundation of China(Nos.20774094; 20874097);the "100 Talents Program" of the Chinese Academy of Sciences(No.KGCX2-YW-802);the Project of Jilin Provincial Science and Technology Department; China(No.20082104).

摘　　要：A new kind of biodegradable pH-sensitive drug delivery system was developed via chitosan-albumin conjugate hydrogel. Through changing the feeding modes of reactants, two types of hydrogels（comb-type and reticular-type） were synthesized by amidation reactions between 6-O-succinoylated N-phthaloyl chitosan and albumin. The structures and morphologies of the hydrogels were characterized by SEM. And their water swelling capacity, drug loading and releasing properties at different pH values were also investigated. It was found that the comb-type of hydrogels with looser space construction had better water swelling ratio（more than 400% of its original mass） than the reticular-type of ones did（about 180% of its original mass）. In vitro release experiments of Rifampicin show that the hydrogels provided the controlled release of the entrapped drug for more than 50 h. The drug release rates of both types of hydrogels under acidic condition were lower than those under neutral or basic condition. The introduction of albumin not only improved the hydrophilicity of chitosan, but also provided the possibility of the carrier system combining other biologically active materials more easily to fulfill the delivery and therapy functions.A new kind of biodegradable pH-sensitive drug delivery system was developed via chitosan-albumin conjugate hydrogel. Through changing the feeding modes of reactants, two types of hydrogels（comb-type and reticular-type） were synthesized by amidation reactions between 6-O-succinoylated N-phthaloyl chitosan and albumin. The structures and morphologies of the hydrogels were characterized by SEM. And their water swelling capacity, drug loading and releasing properties at different pH values were also investigated. It was found that the comb-type of hydrogels with looser space construction had better water swelling ratio（more than 400% of its original mass） than the reticular-type of ones did（about 180% of its original mass）. In vitro release experiments of Rifampicin show that the hydrogels provided the controlled release of the entrapped drug for more than 50 h. The drug release rates of both types of hydrogels under acidic condition were lower than those under neutral or basic condition. The introduction of albumin not only improved the hydrophilicity of chitosan, but also provided the possibility of the carrier system combining other biologically active materials more easily to fulfill the delivery and therapy functions.

关 键 词：CHITOSAN ALBUMIN HYDROGEL pH Sensitive Drug delivery 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业] TS195.5[轻工技术与工程—纺织化学与染整工程]