糖耐量减低患者血清瘦素与内皮素-1的测定及其临床意义  

The significance of serum level of Leptin and ET-1 in patients with impaired glucose toleranc

作　　者：付建芳[1] 涂艳阳[2] 付菊芳[1] 高彬[1] 王莉[1] 邢影[1] 翟文松[1] 赵昕[1] 姬秋和[1] 

机构地区：[1]第四军医大学西京医院内分泌代谢科,陕西西安710032 [2]第四军医大学唐都医院急诊科,陕西西安710032

出　　处：《现代生物医学进展》2011年第5期902-904,914,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨糖耐量减低(IGT)患者血清瘦素(Leptin)和血浆内皮素-1(ET-1)含量变化及其意义。方法:采用放射免疫法检测65例IGT患者、50名正常健康体检者和50例2型糖尿病患者血清中Leptin和ET-1的含量,同时分别测定体重指数、腰臀比、空腹血糖(FBG)、餐后2小时血糖(2h PBG)及空腹胰岛素(FINS),并用HOMA稳态模型计算胰岛素抵抗指数(HOMA-IR)。结果:糖尿病组、IGT组血清Leptin、ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数显著高于正常对照组(P<0.05),糖尿病组血清Leptin、ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数明显高于IGT组(P<0.05)。IGT组血清Leptin水平与BMI、血清ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数呈显著正相关(P<0.01),IGT组血清ET-1水平与收缩压、舒张压、BMI、血清FBG、2hPBG、FINS含量及HOMA-IR指数呈显著正相关(P<0.01)。结论:瘦素与内皮素-1均可能在IGT发展成2型糖尿病过程中起一定的作用。Objective：To investigate the significance of serum level of Leptin and ET-1 in patients with impaired glucose toleranc（IGT）.Methods：Serum level of Leptin and ET-1 in 65 patients with IGT,50 subjects with healthy people,and 50 patients with type 2 diabetes mellitus（DM）were detected by ELISA.Body mass index（BMI）,WHR,FBG,2h PBG and FINS were detected.The insulin resistance by homeostasis model assessment（HOMA-IR） was calculated.Results：Serum level of Leptin,ET-1,FBG,2hPBG,FINS,TC and HOMA-IR in DM group and IGT group were higher than those in the control group.Serum level of Leptin,ET-1,FBG,2hPBG,FINS,TC and HOMA-IR in DM group were higher than those in IGT group.Serum level of Leptin in IGT group were correlated with BMI,while the serum level of ET-1,FBG,2hPBG,FINS,TC and HOMA-IR.Serum level of ET-1 in IGT group were correlated with SBP,DBP,BMI,serum level of FBG,2hPBG,FINS and HOMA-IR.Conclusions：Serum level of Leptin and ET-1 may play a role in the pathogenesis from IGT to type 2 diabetes.

关 键 词：糖耐量减低 瘦素 内皮素 

分 类 号：R587.1[医药卫生—内分泌]