肺炎支原体肺炎患儿血清细胞因子、高敏C反应蛋白、总免疫球蛋白及补体C的检测及其临床意义  

Clinical significance of serum cytokines, high-sensitivity C-reactive protein, immunoglobulin and complement C levels in children with mycoplasma pneumoniae pneumonia

作　　者：郭晓辉[1] 孙艳峰[2] 郭山春[1] 郑振文[1] 汤福广[1] 

机构地区：[1]山东省滨州市人民医院儿科,256600 [2]山东省滨州市人民医院肿瘤科,256600

出　　处：《中国医师进修杂志》2011年第10期28-30,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨检测肺炎支原体肺炎（MPP）患儿血清白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α、高敏C-反应蛋白（hs-CRP）、总免疫球蛋白（Ig）、补体C的临床意义.方法 选择61例MPP患儿（观察组）和60例健康儿童（对照组）为研究对象,IL-6、IL-8采用酶联免疫吸附试验方法测定,TNF-α采用γ放射免疫计数器检测,hs-CRP、总Ig、补体C采用速率散射比浊法测定.结果 观察组血清IL-6为（109.31±54.72）ng/L、IL-8为（128.19±65.87）ng/L、血清hs-CRP为（34.13±19.21）mg/L、总Ig为（12.62±5.51）g/L、补体C为（2.98±0.97）g/L,与对照组的（67.23±32.18）ng/L、（31.78±8.91）ng/L、（1.62±1.34）g/L、（6.71±3.65）g/L、（1.46±0.45）g/L比较均显著上升,差异有统计学意义（P＜0.05或＜0.01）;两组血清TNF-α水平差异无统计学意义（P＞0.05）.结论 IL-6、IL-8、hs-CRP、总Ig及补体C在小儿MPP中起重要作用,检测IL-6、IL-8、hs-CRP、总Ig及补体C的变化对判定病情和预后有一定的临床应用价值.Objective To investigate the clinical significance of serum interleukin （IL）-6,IL-8,tumor necrosis factor （TNF）- α, high-sensitivity C-reactive protein （hs-C RP）, total immunoglobulin （Ig） and complement C levels in children with mycoplasma pneumoniae pneumonia （MPP）. Methods Sixty-one cases of children with MPP （observation group） and 60 healthy children （control group） were selected. The serum IL-6 and IL-8 levels were tested by enzyme linked immunosorbent assay（ELISA） method; the serum TNF-α level was tested by γ radioimmunoassay （RIA） counter; the serum hs-CRP, total Ig and complement C levels were tested by rate nephelometry method. Results The serum IL-6 concentration was （109.31 ±54.72） ng/L, IL-8 concentration was （128.19 ±65.87） ng/L, hs-CRP concentration was （34.13 ± 19.21） mg/L, total Ig concentration was （12.62 ± 5.51） g/L and complement C concentration was （2.98 ± 0.97） g/L in the observation group, and they were higher than those in the control group [（67.23 ±32.18） ng/L, （31.78 ±8.91） ng/L, （1.62 ±1.34） g/L, （6.71 ±3.65） g/L, （1.46 ±0.45） g/L]. The differences were significant （P 〈 0.05 or 〈 0.01）. The serum TNF- t level between two groups had no significant difference （P〉 0.05）. Conclusions The serum cytokines IL-6 and IL-8, hs-CRP, total Ig and complement C play an important role in MPP. It has important significance to detect the serum cytokines IL-6 and IL-8, hs-CRP, total Ig and complement C levels in children with MPP.

关 键 词：肺炎 支原体 白细胞介素类 C反应蛋白质 免疫球蛋白类 补体C 

分 类 号：R725.6[医药卫生—儿科]