2型糖尿病合并非酒精性脂肪性肝病患者的临床特点和危险因素分析  

Analysis of Clinical Characteristics and Risk Factors of Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease

作　　者：楼雪勇[1] 陈光明[1] 朱伟萍[1] 陈英刚[1] 王姗姗[1] 

机构地区：[1]金华市中心医院内分泌代谢科,浙江金华321000

出　　处：《中国现代医生》2011年第8期138-139,155,共3页China Modern Doctor

摘　　要：目的探讨2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)的临床特点和危险因素。方法 226例住院T2DM患者,根据腹部超声检查结果分为合并NAFLD组102例,不合并NAFLD组124例,将以上两组资料与135例单纯NAFLD患者进行比较,分析T2DM合并NAFLD患者的临床特点和危险因素。结果对照组患者BMI、TG、LDL-C、LDL-C、UA较T2DM合并NAFLD及不合并NAFLD组均有显著增高(P<0.01)。T2DM合并NAFLD组患者的BMI、SBP、TG、LDL-C、AST、ALT、WC、FINS、2HINS较不合并NAFLD组显著增高(P<0.01),而HDL-C、2HPG显著降低(P<0.01)。Logistic逐步回归分析结果显示:BMI、TG、WC升高是T2DM合并NAFLD的危险因素。结论 T2DM合并NAFLD与肥胖、血脂紊乱相关。Objective To analyze the clinical characteristics and risk factors of type 2 diabetes mellitus with NAFLD. Methods A total of 226 Type 2 diabetes mellitus （T2DM） patients were categorized into with fatty liver group （n=77）and without fatty liver group （n=124） by ultrasonography,46 patients without diabetes but with NAFLD were served as control.Compared the clinical characteristics and analyzed the risk factors of T2DMwith NAFLD. Results BMI,TG,LDL-C,LDL-C,UA of control group higher than the T2DM NAFLD group merger and T2DM do not merge NAFLD group,were significantly different （P〈0.01,Table 1）.BMI,SBP,TG,LDL-C, AST,ALT,WC,FINS,2HINS of T2DM combined NAFLD group higher than the T2DM NAFLD not merged group,were significantly different （P〈0.01）,HDL-C,2HPG was significantly lower than T2DM NAFLD group （P〈0.01,Table 2）.Logistic regression analysis showed that BMI,TG,waist circumference were risk factors for NAFLD. Conclusion Obesity and disorder of blood lipids contribute the incidence of NAFLD in T2DM patients.

关 键 词：2型糖尿病 非酒精性脂肪性肝病 危险因素 

分 类 号：R587.1[医药卫生—内分泌]