Genes and regulatory networks involved in persistence of Mycobacterium tuberculosis  

作　　者：WANG XiaoZhen WANG HongHai XIE JianPing 

机构地区：[1]Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China [2]State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China

出　　处：《Science China(Life Sciences)》2011年第4期300-310,共11页中国科学（生命科学英文版）

基　　金：supported by the National Key Infectious Disease Project (Grant Nos.2008ZX10003-006 and 2008ZX10003-001);the Excellent PhD Thesis Fellowship of Southwest University(Grant Nos.kb2009010 and ky2009009);the Fundamental Research Funds for the Central Universities (Grant No.XDJK2009A003);the Natural Science Foundation Project of CQ CSTC(Grant No.CSTC,2010BB5002);the National Natural Science Foundation of China(Grant No.81071316)

摘　　要：The causative agent of tuberculosis,Mycobacterium tuberculosis,is one of the most successful of human pathogens.It can evade the host immune response and establish a persistent infection or enter a dormant state within the host which can be reactivated if the host becomes immuno-compromised.Both of these features are major obstacles to tuberculosis eradication.Dormancy and reactivation of M.tuberculosis are tightly coordinated dynamic processes involving numerous genes and their products.Molecular mechanisms underlying M.tuberculosis persistence may provide an opportunity for the discovery of effective drug targets for tuberculosis control.Here,we review the genes required for M.tuberculosis persistence and propose a regulatory network for the action of these genes using text mining.This should provide fresh insights into the persistence mechanisms of M.tuberculosis and suggest candidates for new drug targets and immune intervention.The causative agent of tuberculosis, Mycobacterium tuberculosis, is one of the most successful of human pathogens. It can evade the host immune response and establish a persistent infection or enter a dormant state within the host which can be reactivated if the host becomes immuno-compromised. Both of these features are major obstacles to tuberculosis eradication. Dormancy and reactivation of M. tuberculosis are tightly coordinated dynamic processes involving numerous genes and their products. Molecular mechanisms underlying M. tuberculosis persistence may provide an opportunity for the discovery of effective drug targets for tuberculosis control. Here, we review the genes required for M. tuberculosis persistence and propose a regulatory network for the action of these genes using text mining. This should provide fresh insights into the persistence mechanisms of M. tuberculosis and suggest candidates for new drug targets and immune intervention.

关 键 词：Mycobacterium tuberculosis persistent infection DORMANCY NETWORK 

分 类 号：S858.23[农业科学—临床兽医学] Q253[农业科学—兽医学]