Spontaneous high-frequency action potential  

作　　者：Wonchae CHOE 

机构地区：[1]Department of Biochemistry and Molecular Biology,Medical Research Center and Biomedical Science Institute,School of Medicine,Kyung Hee University

出　　处：《Science China(Life Sciences)》2011年第4期311-335,共25页中国科学（生命科学英文版）

基　　金：supported by a grant of the Korean Health Technology R&D Project,Ministry for Health,Welfare & Family Affairs,Republic of Korea(Grant No.A 092125)

摘　　要：Action potential,which is the foundation of physiology and electrophysiology,is most vital in physiological research.This work starts by detecting cardiac electrophysiology(tachyarrhythmias),combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain,elaborates from generation,induction,initiation,to all of the features of spontaneous high-frequency action potential--SSL action potential mechanism,i.e.,connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic membrane.This work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias,wounds,denervation supersensitivity,neurogenic pain(hyperalgesia and allodynia),epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years.Action potential, which is the foundation of physiology and electrophysiology, is most vital in physiological research. This work starts by detecting cardiac electrophysiology （tachyarrhythmias）, combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain, elaborates from generation, induction, initiation, to all of the features of spontaneous high-frequency action potential--SSL action potential mechanism, i.e., connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic membrane. This work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias, wounds, denervation supersensitivity, neurogenic pain （hyperalgesia and allodynia）, epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years.

关 键 词：action potential spontaneous high-frequency action potential TACHYARRHYTHMIAS atrial fibrillation wound denervation supersensitivity neurogenic pain hyperalgesia and allodynia epileptic discharge diabetic pain regeneration and development 

分 类 号：Q41[生物学—生理学]