心痛康颗粒剂对血小板聚集和心肌缺氧的影响  

Effects of Xin Tong Kang Granules on Platelet Function and Oxygen Deficiency Tolerance

作　　者：陆益红[1] 金卫红[1] 曹苹[2] 

机构地区：[1]江苏省药品检验所,南京210008 [2]深圳市药品检验所,深圳518026

出　　处：《药学进展》1999年第5期303-305,共3页Progress in Pharmaceutical Sciences

摘　　要：应用比浊法观测了心痛康颗粒剂在体外、体内的抗血小板聚集作用及其对异丙肾上腺素所致心肌缺氧的影响。结果表明：在体外，心痛康颗粒剂能抑制由ＡＤＰ诱导的兔血小板聚集，ＩＣ５０ 为３．０ｍ ｇ／ｍ ｌ；给小鼠连续７ 天灌服心痛康颗粒剂（０．５， １．０， ２．０ｇ／ｋｇ）后，并能显著抑制由ＡＤＰ诱导的血小板聚集作用，且能明显延长实验性心肌缺氧小鼠在缺氧条件下的存活时间。In vitro experiment, Xin Tong Kang Granules showed marked inhibitory effect on rabbit platelet aggregation induced by ADP. The IC 50 was 3.0mg/ml. In vivo experiment ,Xin Tong Kang Granules also inhibited platelet aggregation by ADP, remarkablely. Besides, Xin Tong Kang Granules promoted the tolerance of experimental mice to hypoxia.

关 键 词：心痛康颗粒剂 血小板聚集 耐缺氧 中药 

分 类 号：R286.2[医药卫生—中药学]