建立肠易激综合征中医证候模型的研究  

Establishment of Irritable Bowel Syndrome for Traditional Chinese Medicine Model

作　　者：谭洁[1] 马薇[1] 彭芝配[1] 滕久祥[1] 龙霖梓[1] 殷坚[1] 王丽[1] 

机构地区：[1]湖南中医药大学,长沙410007

出　　处：《中国实验方剂学杂志》2011年第8期197-199,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：湖南省教育厅基金项目(09C732)

摘　　要：目的:通过将慢性应激动物模型与脾胃湿热证模型相结合的方式探讨肠易激综合征(IBS)中医证候动物模型的建立。方法:30只SD大鼠随机分为3组;空白组、模型Ⅰ组(脾胃湿热证组)、模型Ⅱ组(复合模型组),每组10只,除空白组外,模型Ⅰ组、Ⅱ组都予以脾胃湿热造模,其中模型Ⅱ组同时予以肠易激综合征慢性应激造模,造模结束时观察大鼠体质量、体温、粪便性状等生理指标和肠道组织学改变。结果:模型Ⅰ,Ⅱ组的一般情况、体质量、体温、粪便性状及行为等方面与空白组比较差异有统计学意义(P<0.05),而在肠道组织学方面无明显改变。结论:湿热泄泻型慢性应激脾胃湿热证结合IBS大鼠模型在一定程度上与人类腹泻型IBS(脾胃湿热型)相似,并有较好的可重复性。Objective：By chronic stress and spleen damp-heat to explore the combination of traditional Chinese medicine syndrome with IBS in animal model.Method：Thirty SD rats were randomly divided into 3 groups,namely：the blank group,model groupⅠ（Spleen and Stomach Damp-heat group）,model groupⅡ（composite model group）,each of 10 rats.Except the blank group,the model groupⅠand group Ⅱwere the spleen damp-heat modeling groups.However groupⅡwas simultaneously with irritable bowel syndrome by chronic stress methods.By the end,the physiological indices of rats and histological changes were investigated.Result：In the model groups,body weight,body temperature,fecal character and behavior were significant different compared with the control group（P 〈 0.05）.However in the intestine there was no significant histological difference.Conclusion：Damp-heat diarrhea-type IBS of rat model is to some extent to human diarrhea-predominant IBS（spleen type） with good repeatability.

关 键 词：中医证候 湿热泄泻型 肠易激综合征 动物模型 

分 类 号：R285.5[医药卫生—中药学]